{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:48:52Z","timestamp":1791532132620,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive reappraisal has been extensively investigated using fMRI, yet the neural mechanisms underlying up\u2010 versus down\u2010regulation of negative emotion remain incompletely understood. This study aimed to examine brain activation and task\u2010dependent functional connectivity for both regulatory goals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A well\u2010established cognitive reappraisal task was employed during an fMRI scan, with 21 participants instructed to up\u2010 and down\u2010regulate negative emotions by mentally reinterpreting the stimuli. Whole\u2010brain activation analyses included a conjunction\u2010null analysis and differential contrasts to identify shared and goal\u2010specific activation. Generalized psychophysiological interaction (gPPI) analyses were also performed to examine task\u2010dependent functional connectivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Down\u2010regulation primarily engaged the ventrolateral prefrontal cortex (VLPFC) and middle temporal gyrus (MTG), whereas up\u2010regulation recruited prefrontal regions and the left insula. The conjunction\u2010null analysis revealed common activation in a predominantly left\u2010lateralized frontoparietal\u2013medial frontal network beyond viewing negative pictures. Differential contrasts showed that up\u2010regulation specifically recruited the left postcentral gyrus, whereas down\u2010regulation specifically recruited occipital regions and the right dorsolateral prefrontal cortex (DLPFC). In exploratory and uncorrected gPPI analyses, during down\u2010regulation, the VLPFC was positively coupled with the right MTG, whereas during up\u2010regulation, the left DLPFC was coupled with the left insula and dorsal striatum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that up\u2010 and down\u2010regulation share a common frontoparietal\u2013medial frontal network, but differ in goal\u2010specific activation and connectivity patterns. Down\u2010regulation may rely more on cognitive and semantic processing, whereas up\u2010regulation may involve reward\u2010related and interoceptive mechanisms. Given the exploratory nature of the gPPI findings, the connectivity results should be considered preliminary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71821","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:26Z","timestamp":1791528566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Magnetic Resonance Imaging Correlates of Cognitive Reappraisal of Negative Emotion: A Brain Activation and Generalized Psychophysiological Interaction Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Yuluo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Forensic Science Guangdong Police College  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Daping Hospital Army Medical University  Daping Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longda","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wuhan Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9804-9619","authenticated-orcid":false,"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science Guangzhou Health Science College  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsm029"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2021.107767"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283503669"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20109004.2009.00186.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1093\/cercor\/bht154","article-title":"Cognitive Reappraisal of Emotion: A Meta\u2010Analysis of Human Neuroimaging Studies","volume":"24","author":"Buhle J. 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