{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:49:22Z","timestamp":1792172962148,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the neurobiological basis of procedural learning and retention of motor memories in aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We used a modified serial reaction time (SRT) task with feedback in two age groups: young (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018, 24.9\u00a0\u00b1\u00a03.9 years, range: 18\u201332 years) and older (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019, 63.5\u00a0\u00b1\u00a05.1 years, range: 54\u201373 years) healthy participants. We assessed procedural learning while participants underwent functional magnetic resonance imaging (fMRI, Day 1). On the following day, we assessed retention behaviorally outside the scanner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>\n                      Both groups showed significant procedural learning (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and retention (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Notably, retention was enhanced in older compared to younger adults (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), even after normalizing the reaction time (RT) gains to individual RT (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Functional imaging revealed more robust recruitment of the left sensorimotor cortex (SM1) during procedural learning in older participants. Besides, left premotor cortex activity during procedural learning predicted retention in both age groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data show that procedural learning was preserved in healthy older adults. At the same time, retention was even enhanced in healthy older adults. These processes were associated with activation changes in the contralateral sensorimotor and premotor cortices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71845","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:15:22Z","timestamp":1792170922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Procedural Learning and Retention in Older Subjects: The Contribution of Sensorimotor and Premotor Cortex"],"prefix":"10.1002","volume":"16","author":[{"given":"Christopher E. J.","family":"Doppler","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Forschungszentrum J\u00fclich  J\u00fclich Germany"},{"name":"Department of Neurology, Faculty of Medicine University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Alexius\/Josef Hospital  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Weidner","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Forschungszentrum J\u00fclich  J\u00fclich Germany"},{"name":"Department of Neurology, Faculty of Medicine University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Forschungszentrum J\u00fclich  J\u00fclich Germany"},{"name":"Department of Neurology, Faculty of Medicine University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.049"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.008"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059490"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.7.2.220"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JADD.0000022607.19833.00"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.11.010"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00076"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006683"},{"issue":"2","key":"e_1_2_13_12_1","first-page":"891","article-title":"Human Memory and the Medial Temporal Region of the Brain","volume":"34","author":"Corsi P. 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