{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:34:53Z","timestamp":1792924493458,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471368"],"award-info":[{"award-number":["82471368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The glymphatic system plays a critical role in cerebral metabolite clearance and white matter injury. However, its clinical relevance in intracerebral hemorrhage (ICH) remains poorly understood. This study aimed to investigate imaging\u2010based glymphatic markers in relation to functional outcomes and cerebral small vessel disease (CSVD) burden in patients with ICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 70 patients with acute supratentorial ICH who underwent diffusion tensor imaging (DTI). Glymphatic\u2010related imaging parameters were derived using magnetic resonance imaging (MRI), including DTI\u2010ALPS, free water (FW) fraction, and relative perivascular space (PVS) volume. CSVD burden was assessed using relative white matter hyperintensity (WMH) volume and number of lacunes. Functional independence was defined as a 3\u2010month modified Rankin Scale score of 0\u20132.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In fully adjusted logistic regression models, higher FW in deep WM was associated with a lower likelihood of functional independence at 3 months (OR = 0.59; 95% CI, 0.36\u20130.98; p = 0.041), with consistent findings across sequential models. Linear regression analyses further demonstrated that greater relative WMH volume was significantly associated with increased FW in deep WM (\u03b2 = 0.143; 95% CI, 0.008\u20130.277;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038) and with smaller relative PVS volume in fully adjusted models. Neither FW association remained statistically significant after FDR correction. The FW\u2013outcome association was also nonsignificant after adjustment for WMH burden, and the exploratory mediation analysis showed no statistically significant indirect effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Contralateral FW showed nominal associations with functional outcome and WMH burden and may reflect diffuse CSVD\u2010related white matter injury. Its independent prognostic and mediating roles remain unestablished and require validation in larger longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.71856","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:10:31Z","timestamp":1792170631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Glymphatic Imaging Markers With Clinical Outcomes and Cerebral Small Vessel Disease Burden After Intracerebral Hemorrhage"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1295-3293","authenticated-orcid":false,"given":"Xiao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-3101","authenticated-orcid":false,"given":"Zuoqiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7974-7075","authenticated-orcid":false,"given":"Zijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshuo","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui 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