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The aim of our study was to investigate the association between cognitive performance and motor dysfunction in Chinese patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 96 patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were obtained from the Parkinson's disease patient cohort database of Huashan Hospital. All participants underwent a comprehensive neuropsychological evaluation to assess cognitive status, that included scoring on the Mini\u2010mental state examination (<jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>), followed by more detailed cognitive assessment on five main cognitive domains (verbal memory, nonverbal memory, visuospatial function, language and attention\/executive function). Correlations between cognitive and motor scores were investigated after controlling for age, disease duration, education, and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report a significant correlation between subdomains of cognitive impairment and motor dysfunction using analyses of the multiple linear regression. Notably, executive function and attention was significantly associated with bradykinesia and rigidity, while visuospatial function was associated with bradykinesia and tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between motor dysfunction and cognitive decline in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> might highlight deficits represented by a shared neurochemical pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.719","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T09:06:50Z","timestamp":1494580010000},"source":"Crossref","is-referenced-by-count":49,"title":["Associations between cognitive impairment and motor dysfunction in Parkinson's disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Yi\u2010Xuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department &amp; Institute of Neurology Huashan Hospital &amp; National Clinical Research 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