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(I) There was less grey matter in the predominantly right precuneus in the essential tremor group compared to controls [<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001]. (<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) In <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients mean, axial, and radial diffusivity values broadly correlated with the tremor rating scale, pronounced in fronto\u2010parietal regions [<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05]. (<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) In <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients there was a significant decline in fractional anisotropy values in the corpus callosum in the correlation with verbal fluency results [<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05]; by inclusion of the tremor rating scale as covariate of no interest this significance was however diminished to a tendency (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.1). No significant results were found in these within\u2010group correlations in grey matter analyses for <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results indicate that non\u2010motor symptoms such as verbal fluency (<jats:styled-content style=\"fixed-case\">VBF<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> have a structural substrate; their reproduction requires the integration of potential environmental plasticity effects, differentiation into individual clinical subtypes and a careful handling with methodological peculiarities of structural <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.722","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T07:52:45Z","timestamp":1494834765000},"source":"Crossref","is-referenced-by-count":11,"title":["Structural differences in impaired verbal fluency in essential tremor patients compared to healthy controls"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-5973","authenticated-orcid":false,"given":"Esther A.","family":"Pelzer","sequence":"first","affiliation":[{"name":"Max Planck Institute for Metabolism Research Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Nelles","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Eggers","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lothar","family":"Burghaus","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Melzer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Metabolism Research Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Tittgemeyer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Metabolism Research Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5334\/tohm.227","article-title":"Essential tremor: A neurodegenerative disease?","volume":"4","author":"Benito\u2010Leon J.","year":"2014","journal-title":"Tremor and Other Hyperkinetic Movements"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.037"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0347"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001936"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4138"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1544"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.06.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000240130.94408.99"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25819"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2004.03.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2005.11.045"},{"key":"e_1_2_8_16_1","unstructured":"Fahn S. 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