{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:49:08Z","timestamp":1780494548335,"version":"3.54.1"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In geriatric clinical diagnostics, gait analysis with cognitive\u2010motor dual tasking is used to predict fall risk and cognitive decline. To date, the neural correlates of cognitive\u2010motor dual tasking processes are not fully understood. To investigate these underlying neural mechanisms, we designed an <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> paradigm to reproduce the gait analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested the <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> paradigm\u2019s feasibility in a substudy with fifteen young adults and assessed 31 healthy older adults in the main study. First, gait speed and variability were quantified using the <jats:styled-content style=\"fixed-case\">GAITR<\/jats:styled-content>ite<jats:sup>\u00a9<\/jats:sup> electronic walkway. Then, participants lying in the <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010scanner were stepping on pedals of an <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010compatible stepping device used to imitate gait during functional imaging. In each session, participants performed cognitive and motor single tasks as well as cognitive\u2010motor dual tasks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Behavioral results showed that the parameters of both gait analyses, <jats:styled-content style=\"fixed-case\">GAITR<\/jats:styled-content>ite<jats:sup>\u00a9<\/jats:sup> and <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>, were significantly positively correlated. <jats:styled-content style=\"fixed-case\">FMRI<\/jats:styled-content> results revealed significantly reduced brain activation during dual task compared to single task conditions. Functional <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> analysis showed that activation in the superior parietal lobe (<jats:styled-content style=\"fixed-case\">SPL<\/jats:styled-content>) decreased less from single to dual task condition than activation in primary motor cortex and in supplementary motor areas. Moreover, <jats:styled-content style=\"fixed-case\">SPL<\/jats:styled-content> activation was increased during dual tasks in subjects exhibiting lower stepping speed and lower executive control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We were able to simulate walking during functional imaging with valid results that reproduce those from the <jats:styled-content style=\"fixed-case\">GAITR<\/jats:styled-content>ite<jats:sup>\u00a9<\/jats:sup> gait analysis. On the neural level, <jats:styled-content style=\"fixed-case\">SPL<\/jats:styled-content> seems to play a crucial role in cognitive\u2010motor dual tasking and to be linked to divided attention processes, particularly when motor activity is involved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.724","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T04:11:00Z","timestamp":1500696660000},"source":"Crossref","is-referenced-by-count":47,"title":["Imaging gait analysis: An <scp>fMRI<\/scp> dual task study"],"prefix":"10.1002","volume":"7","author":[{"given":"C\u00e9line N.","family":"B\u00fcrki","sequence":"first","affiliation":[{"name":"Division of Diagnostic and Interventional Neuroradiology Department of Radiology University of Basel Hospital and University of Basel  Basel Switzerland"},{"name":"Felix Platter\u2010Hospital University Center for Medicine of Aging and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Bridenbaugh","sequence":"additional","affiliation":[{"name":"Felix Platter\u2010Hospital University Center for Medicine of Aging and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Interventional Neuroradiology Department of Radiology University of Basel Hospital and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stippich","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Interventional Neuroradiology Department of Radiology University of Basel Hospital and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto W.","family":"Kressig","sequence":"additional","affiliation":[{"name":"Felix Platter\u2010Hospital University Center for Medicine of Aging and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-5697","authenticated-orcid":false,"given":"Maria","family":"Blatow","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Interventional Neuroradiology Department of Radiology University of Basel Hospital and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.06.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2006.12.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25674"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14640746708400109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws373"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.11.023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2014.03.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.038"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22629"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0247"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322194"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00391-014-0845-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-287-080-3_205-1"},{"key":"e_1_2_8_16_1","unstructured":"Chicherio C.(2006).Contr\u00f4le ex\u00e9cutif et r\u00e9seaux neurofonctionnels au cours du vieillissement normal: Un test de l'hypoth\u00e8se de d\u00e9\u2010diff\u00e9renciation cognitive. 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