{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:00:14Z","timestamp":1773306014648,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Projects of Medical and Health Technology Development Program in Shandong Province","award":["2013WS0105"],"award-info":[{"award-number":["2013WS0105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Subcortical vascular mild cognitive impairment (sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>) is the predementia stage of subcortical vascular dementia (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD). The aim of this research is to explore and compare cerebral gray matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) volume reduction in sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients, and to investigate the relationship between cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction and cognitive deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty one sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients, 29 <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients, and 31 healthy controls were recruited in our research. They conducted neuropsychological tests and brain structural magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) examination. To detect cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction in sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients, we used statistical parametric mapping 8\u2010voxel\u2010based morphometry 8 (<jats:styled-content style=\"fixed-case\">SPM<\/jats:styled-content>8\u2010<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>8) method to analyze <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> data. To detect the relationship between cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction and cognitive deficits, multiple linear regression analysis was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients showed cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction in hippocampus and parahippocampal gyrus, insula and superior temporal gyrus. Compared with healthy controls, <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients exhibited more atrophy which encompasses all of these areas plus anterior and middle cingulate, inferior temporal gyrus, orbitofrontal cortex, and superior frontal gyrus. In sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients, cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction correlated with memory loss, attention dysfunction, and language dysfunction; in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients, besides those cognitive deficits, cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction correlated with more cognitive impairments, including executive dysfunction, neuropsychiatric symptom, and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings prove that both sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients exhibit cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction and there may exist a hierarchy between sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD, and cerebral <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume reduction in both sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients correlates with cognitive deficits, which can help us understand the mechanism of cognitive impairments in sv<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD patients, and diagnose <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>aD at its early stage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.745","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T06:31:37Z","timestamp":1498199497000},"source":"Crossref","is-referenced-by-count":41,"title":["Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-6793","authenticated-orcid":false,"given":"Maoyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Shandong Medical Imaging Research Institute Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Shandong Medical Imaging Research Institute Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Shandong Medical Imaging Research Institute Affiliated to Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333482"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2007.04.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.473"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540080076020"},{"key":"e_1_2_9_6_1","first-page":"23","article-title":"Research criteria for subcortical vascular dementia in clinical trials","volume":"59","author":"Erkinjuntti T.","year":"2000","journal-title":"Journal of Neural Transmission. 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