{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:01:44Z","timestamp":1779138104264,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluates the effect of food intake on 92 neurological biomarkers in plasma. Moreover, it investigated if any of the biomarkers were correlated with body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010two healthy subjects (11 male and 11 female aged 25.9\u00a0\u00b1\u00a04.2\u00a0years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120\u00a0min afterward with the Proseek Multiplex Neurology\u00a0I kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels for 13 biomarkers decreased significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) 30\u00a0min after food intake. The levels for four biomarkers remained significantly decreased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) 120\u00a0min after food intake. One biomarker increased significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) 30\u00a0min after food intake. The changes were between 1% and 12%, with an average difference of about 5%. Only one biomarker showed a difference over 10% due to food intake. The biggest difference was observed for Plexin\u2010B3 120\u00a0min after food intake (12%). Of all the 92 neurological biomarkers, only one was correlated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, Kynureninase <jats:italic>r<\/jats:italic>\u00a0=\u00a0.46, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that food intake has a very modest effect on 92 different neurological biomarkers. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Only Kynureninase was correlated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Further studies are warranted in older healthy subjects and in patients with various neurological diseases to determine whether the findings are reproducible in such populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.747","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T09:36:46Z","timestamp":1501666606000},"source":"Crossref","is-referenced-by-count":15,"title":["Effect of food intake on 92 neurological biomarkers in plasma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-3712","authenticated-orcid":false,"given":"Magnus","family":"Dencker","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Bj\u00f6rgell","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Hlebowicz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Medicine Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01451.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12242"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-12-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-10-26"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-9-43"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3293"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.07.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12473"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010829"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149821"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr424"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S84685"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3874964"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110670"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322702"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:29:00Z","timestamp":1696591740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/brb3.747"],"URL":"https:\/\/doi.org\/10.1002\/brb3.747","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]},"article-number":"e00747"}}