{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:42Z","timestamp":1790232582635,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The recent thrombectomy trials have shown that perfusion imaging is helpful in proper patient selection in thromboembolic stroke. In this study, we analyzed the correlation of pretreatment <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> volumes in <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> perfusion with clinical outcome after thrombectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one consecutive patients with middle cerebral artery occlusion (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>) or carotid T occlusion treated with thrombectomy were included. <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> volumes at delays of &gt;4, 6, 8, and 10\u00a0s as well as infarct core and mismatch ratio were automatically estimated in preinterventional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> perfusion using <jats:styled-content style=\"fixed-case\">RAPID<\/jats:styled-content> software. These perfusion parameters were correlated with clinical outcome. Outcome was assessed using modified Rankin scale at 90\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with successful recanalization of <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> occlusion, <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>\u00a0&gt;\u00a08 and 10\u00a0s showed the best linear correlation with clinical outcome (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.75; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0139 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.73; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0139), better than infarct core (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.43; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.2592). In terminal internal carotid artery occlusions, none of the perfusion parameters showed a significant correlation with clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> at delays of &gt;8 and 10\u00a0s is a good predictor for clinical outcome in <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> occlusions. In carotid T occlusion, however, <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> volumes do not correlate with outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.772","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T08:16:35Z","timestamp":1501056995000},"source":"Crossref","is-referenced-by-count":16,"title":["Correlation of <i>T<\/i><sub>max<\/sub> volumes with clinical outcome in anterior circulation stroke"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-0438","authenticated-orcid":false,"given":"Fatih","family":"Seker","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pfaff","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg 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A.","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg 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