{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:44:00Z","timestamp":1782474240562,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008062","name":"Fundaci\u00f3n Alicia Koplowitz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["GR15012"],"award-info":[{"award-number":["GR15012"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/109043\/2015"],"award-info":[{"award-number":["SFRH\/BPD\/109043\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>TFAP<\/jats:styled-content>2B<\/jats:italic> and KCTD<\/jats:styled-content>15<\/jats:italic> are obesity\u2010related genes that interact to regulate feeding behavior. We hypothesize that variability in these loci, isolated or in combination, could also be related to the risk of eating disorders (ED<\/jats:styled-content>) and\/or associated psychological traits.<\/jats:p><\/jats:sec>Methods<\/jats:title>We screened 425 participants (169 ED<\/jats:styled-content> patients, 75 obese subjects, and 181 controls) for 10 clinically relevant and tag single\u2010nucleotide polymorphisms (SNP<\/jats:styled-content>s) in KCTD<\/jats:styled-content>15<\/jats:italic> and TFAP<\/jats:styled-content>2B<\/jats:italic> by the Sequenom MassARRAY<\/jats:styled-content> platform and direct sequencing. Psychometric evaluation was performed with EDI<\/jats:styled-content>\u20102 and SCL<\/jats:styled-content>\u201090R inventories.<\/jats:p><\/jats:sec>Results<\/jats:title>The KCTD<\/jats:styled-content>15<\/jats:italic> rs287103 T variant allele was associated with increased risk of bulimia nervosa (BN<\/jats:styled-content>) (OR<\/jats:styled-content>\u00a0=\u00a04.34 [1.47\u201329.52]; p<\/jats:italic>\u00a0=\u00a0.003) and with scores of psychopathological scales of these patients. Haplotype *6<\/jats:italic> in KCTD<\/jats:styled-content>15<\/jats:italic> was more frequent in controls (OR<\/jats:styled-content>\u00a0=\u00a00.40 [0.20\u20130.80], p<\/jats:italic>\u00a0=\u00a0.009 for anorexia nervosa), while haplotype *4<\/jats:italic> in TFAP<\/jats:styled-content>2B<\/jats:italic> affected all three scales of the SCL<\/jats:styled-content>\u201090R inventory in BN<\/jats:styled-content> patients (p<\/jats:italic>\u00a0\u2264\u00a0.01). Epistasis analyses revealed relevant interactions with body mass index of BN<\/jats:styled-content> patients (p<\/jats:italic>\u00a0<\u00a0.001). Genetic profiles in obese patients did not significantly differ from those found in ED<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This is the first study that evaluates the combined role of TFAP<\/jats:styled-content>2B<\/jats:italic> and KCTD<\/jats:styled-content>15<\/jats:italic> genes in ED<\/jats:styled-content>. Our preliminary findings suggest that the interaction of genetic variability in these loci could influence the risk for ED<\/jats:styled-content> and\/or anthropometric and psychological parameters.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.784","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T11:52:42Z","timestamp":1501156362000},"source":"Crossref","is-referenced-by-count":21,"title":["Influence of TFAP<\/scp>2B<\/i> and KCTD<\/scp>15<\/i> genetic variability on personality dimensions in anorexia and bulimia nervosa"],"prefix":"10.1002","volume":"7","author":[{"given":"Carmen","family":"Gamero\u2010Villarroel","sequence":"first","affiliation":[{"name":"Department of Medical & Surgical Therapeutics Division of Pharmacology Medical School University of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz M.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Medical & Surgical Therapeutics Division of Pharmacology Medical School University of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Rodr\u00edguez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Service of Clinical Analyses General University Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-9020","authenticated-orcid":false,"given":"David","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Service of Clinical Analyses General University Hospital Valencia Spain"},{"name":"Research Center for Anthropology and Health (CIAS) University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Department of Medical & Surgical Therapeutics Division of Pharmacology Medical School University of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angustias","family":"Garc\u00eda\u2010Herr\u00e1iz","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Institute of Mental Disorders Health Service of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isalud","family":"Flores","sequence":"additional","affiliation":[{"name":"Eating Disorders Unit Institute of Mental Disorders Health Service of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-9767","authenticated-orcid":false,"given":"Guillermo","family":"Gervasini","sequence":"additional","affiliation":[{"name":"Department of Medical & Surgical Therapeutics Division of Pharmacology Medical School University of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2014.23"},{"key":"e_1_2_7_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"Association, A. 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