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Cerebral vasospasm and early brain injury are associated with inflammatory response and oxidative stress. Whether curcumin, which plays important roles to regulate inflammatory cytokines and inhibit oxidative stress, inhibits <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>\u2010induced inflammation and oxidative stress are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult male rats underwent autologous blood injection into prechiasmatic cistern to induce <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>. Curcumin (150\u00a0mg\/kg) was administered at 0.5, 24 and 48\u00a0hr post\u2010<jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>. Mortality calculation and neurological outcomes as well as morphological vasospasm of anterior cerebral artery were studied. Superoxide dismutase, lipid peroxidation, and inflammatory cytokines (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) expression in prefrontal region were quantified. Furthermore, p65 and phosphor\u2010p65 were quantitatively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Curcumin remarkedly reduced mortality and ameliorated neurological deficits after <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content> induction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05); morphological results showed that cerebral vasospasm in curcumin\u2010treated group was mitigated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 overexpression were inhibited in curcumin\u2010treated group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Importantly, phosphor\u2010p65 was significantly inhibited after curcumin treatment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Curcumin can inhibit <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>\u2010induced inflammatory response via restricting <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation to alleviate cerebral vasospasm and early brain injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.790","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T08:36:42Z","timestamp":1502267802000},"source":"Crossref","is-referenced-by-count":28,"title":["Curcumin mitigates cerebral vasospasm and early brain injury following subarachnoid hemorrhage via inhibiting cerebral 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