{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:29:40Z","timestamp":1790166580175,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NT\u201013449\u20104"],"award-info":[{"award-number":["NT\u201013449\u20104"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (\n NMDCCC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n A prospective observational follow\u2010up study was performed in a cohort of 112 consecutive\n NMDCCC<\/jats:styled-content>\n subjects (55 women and 57 men; median age 59\u00a0years, range 40\u201379\u00a0years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow\u2010up of at least 2\u00a0years (median duration 3\u00a0years). Development of clinical signs of degenerative cervical myelopathy (\n DCM<\/jats:styled-content>\n ) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and\n MRI<\/jats:styled-content>\n parameters including diffusion tensor imaging characteristics (\n DTI<\/jats:styled-content>\n ) established at entry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Clinical evidence of the first signs and symptoms of\n DCM<\/jats:styled-content>\n were found in 15 patients (13.4%). Development of\n DCM<\/jats:styled-content>\n was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run\u2010time), electrophysiological (\n SEP<\/jats:styled-content>\n ,\n MEP<\/jats:styled-content>\n and\n EMG<\/jats:styled-content>\n signs of cervical cord dysfunction), and\n MRI<\/jats:styled-content>\n (anteroposterior diameter of the cervical cord and cervical canal, cross\u2010sectional area, compression ratio, type of compression, T2 hyperintensity).\n DTI<\/jats:styled-content>\n parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross\u2010sectional area (\n CSA<\/jats:styled-content>\n )\u00a0\u2264\u00a070.1\u00a0mm\n 2<\/jats:sup>\n , and compression ratio (\n CR<\/jats:styled-content>\n )\u00a0\u2264\u00a00.4 were the only independent significant predictors for progression into symptomatic myelopathy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In addition to previously described independent predictors of\n DCM<\/jats:styled-content>\n development (radiculopathy and electrophysiological dysfunction of cervical cord),\n MRI<\/jats:styled-content>\n parameters, namely\n CSA<\/jats:styled-content>\n and\n CR<\/jats:styled-content>\n , should also be considered as significant predictors for development of\n DCM<\/jats:styled-content>\n .\n <\/jats:p>\n 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