{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:59:43Z","timestamp":1760385583082,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230027","81401127"],"award-info":[{"award-number":["81230027","81401127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["13ZR1460500","13ZR1409700"],"award-info":[{"award-number":["13ZR1460500","13ZR1409700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["13140903400"],"award-info":[{"award-number":["13140903400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The relationship between peripheral 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3A receptor<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>level and risperidone efficiency in paranoid schizophrenia patients is still unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total 52 first\u2010episode and drug\u2010naive paranoid schizophrenia patients who were treated with risperidone and 53 matched healthy controls were enrolled. Patients were naturalistically followed up for 8\u00a0weeks. Positive and Negative Syndrome Scale (<jats:styled-content style=\"fixed-case\">PANSS<\/jats:styled-content>)\u00a0was applied to assess symptom severity of the patients at baseline and at the end of 8th week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3A receptor<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>level between paranoid schizophrenia patients and healthy controls at baseline (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.24). Among 47 patients who completed 8\u2010week naturalistic follow\u2010up, 37 were responders to risperidone treatment. 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3A receptor<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>level of paranoid schizophrenia patients did not change in overall patients after 8\u2010week treatment with risperidone (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.29). However, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3A receptor<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>level in responders increased significantly (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.04), but not in nonresponders (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Successful treatment with risperidone increases 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3A receptor gene expression in patients with paranoid schizophrenia, indicating that 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3A receptor may be involved in the mechanism of risperidone effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.798","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T01:36:39Z","timestamp":1502674599000},"source":"Crossref","is-referenced-by-count":8,"title":["Successful treatment with risperidone increases 5\u2010<scp>HT<\/scp>3A receptor gene expression in patients with paranoid schizophrenia \u2013 data from a prospective study"],"prefix":"10.1002","volume":"7","author":[{"given":"Hongying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Department of Psychiatry Changning Mental Health Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qingdao Mental Health Center Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qingdao Mental Health Center Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiajun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangtai","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-9945","authenticated-orcid":false,"given":"Zezhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1097\/FPC.0b013e3283659a94"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1111\/j.1471-4159.2007.04945.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1038\/16941"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1523\/JNEUROSCI.2999-05.2005"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1097\/FBP.0000000000000102"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/S0301-0082(98)00074-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1097\/FPC.0b013e32830500e2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/j.schres.2014.12.031"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1111\/j.1600-0447.2008.01308.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1176\/ajp.155.6.741","article-title":"Genome scan of schizophrenia","volume":"155","author":"Levinson D. 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