{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:22:12Z","timestamp":1764044532547,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology, ROC","award":["MOST103-2321-B-002-019","MOST106-2314-B-002-189"],"award-info":[{"award-number":["MOST103-2321-B-002-019","MOST106-2314-B-002-189"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Palmar hyperhidrosis (PH) exhibits excessive and unpredictable sweating. The most effective treatment for permanent cure is the ablation of thoracic sympathetic ganglia innervating hands. However, sympathectomy of T2 sympathetic ganglion by clipping or cauterization causes irreversible nerve damage, and results in a compensatory hyperhidrosis (CH). We herein used the pulsed radiofrequency (PRF) stimulation to reversibly block sympathetic ganglion to treat PH and avoid CH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A bipolar electrode was implanted into the right T2 sympathetic trunk by endoscopic surgery and PRF was delivered through the electrode. The humidity (%) of right palm was measured to indicate sweating level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six out of 13 rats (46.2%) that received a 5\u2010min PRF stimulation on the T2 sympathetic trunk showed a decrease in the right palm humidity during the surgery. PRF stimulation significantly reduced humidity from 69.17%\u00a0\u00b1\u00a00.72% obtained from baseline condition to 66.93%\u00a0\u00b1\u00a00.69%. The humidity reduction was also observed at 10\u00a0min after the PRF stimulation. We further evaluated the effect of PRF stimulation 1\u00a0week after surgery and found that the PRF stimuli reduced right hand humidity in 5 out of 8 rats (62.5%). PRF stimulation significantly reduced humidity from 66.11%\u00a0\u00b1\u00a00.81% obtained from sham operation control to 63.62%\u00a0\u00b1\u00a00.82%. The percentage of right hand humidity obtained 10\u00a0min after PRF stimulation was also reduced to 63.38%\u00a0\u00b1\u00a00.80%. Anesthetics have no effect on humidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that PRF stimulation of T2 sympathetic trunk reduces palm sweating in rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.833","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T09:03:07Z","timestamp":1506416587000},"source":"Crossref","is-referenced-by-count":5,"title":["Pulsed radiofrequency stimulation suppresses palmar hyperhidrosis in an animal study"],"prefix":"10.1002","volume":"7","author":[{"given":"Mu\u2010Lien","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Medical School National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Pain Clinic Taipei City Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Rung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine School of Veterinary Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chien","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Surgery National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Wei","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering National Taipei University of Technology  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-5416","authenticated-orcid":false,"given":"Fang\u2010Chia","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine School of Veterinary Medicine National Taiwan University  Taipei Taiwan"},{"name":"Graduate Institute of Brain &amp; Mind Sciences College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Graduate Institute of Acupuncture Science College of Chinese Medicine China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.04.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2008.01.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2008.04.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770931"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299573"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200101000-00037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2008.01.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200210000-00021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2008.01.007"},{"key":"e_1_2_9_11_1","first-page":"503","article-title":"The neurostimulator in loco\u2010regional anesthesia","volume":"40","author":"Dupr\u00e9 L. 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