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Sphingolipids have been implicated in the pathophysiology of both <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> and depression. This study assessed the association between plasma sphingolipid concentrations and depressive symptoms in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Depressive symptoms were measured using the depression subscale of the self\u2010reported Hospital Anxiety and Depression Scale (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>). Sphingolipid concentrations were measured from fasting plasma samples using high\u2010performance liquid chromatography\u2010coupled electrospray ionization tandem mass spectrometry (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). Linear regression models were used to assess associations between log\u2010transformed concentrations of plasma sphingolipids and depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 111 <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients (mean (<jats:italic>SD<\/jats:italic>) age\u00a0=\u00a063.6\u00a0\u00b1\u00a06.4, 84.7% male) were included. In linear regression analyses, higher plasma concentrations of ceramides C16:0 (\u03b2\u00a0=\u00a00.204, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.026) and C18:0 (\u03b2\u00a0=\u00a00.209, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.023) and sphingomyelin <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>18:1 (\u03b2\u00a0=\u00a00.210, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024) were significantly associated with higher <jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content> depression subscale score after adjusting for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sphingolipids, in particular the ceramide species C16:0 and C18:0 and the sphingomyelin species <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>18:1, may be implicated in the pathophysiology of depression in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. The association between plasma sphingolipid concentrations and depression should be further examined in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients and in other populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.836","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T02:37:01Z","timestamp":1506479821000},"source":"Crossref","is-referenced-by-count":28,"title":["Plasma sphingolipids and depressive symptoms in coronary artery disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Adam","family":"Dinoff","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology Research Group Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto ON Canada"},{"name":"Department of Pharmacology and Toxicology Faculty of Medicine University of Toronto  Toronto ON 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