{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:14:28Z","timestamp":1774491268474,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Involvement of the neuromuscular junction (<jats:styled-content style=\"fixed-case\">NMJ<\/jats:styled-content>) in amyotrophic lateral sclerosis (<jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>) has been reported and is increasingly recognized as an important pathophysiological aspect. The relationship between decrement and clinical measures for possible application as a biomarker has not been comprehensively explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed routine repetitive nerve stimulation (<jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content>) of three nerves on patients with <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>. We captured measures of muscle strength, grip strength, fatigability, and calculated slow vital capacity (<jats:styled-content style=\"fixed-case\">SVC<\/jats:styled-content>) rates of change assessing for associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 42 subjects, 210 muscles were studied. Negative correlation was found between the percentage of decrement and compound muscle action potential (<jats:styled-content style=\"fixed-case\">CMAP<\/jats:styled-content>) amplitude. Approximately half of the patients with hand weakness did not have decrement. There was no significant correlation between decrement and handgrip fatigue, <jats:styled-content style=\"fixed-case\">SVC<\/jats:styled-content>\u00a0&lt;\u00a080% predicted, or more rapid worsening of <jats:styled-content style=\"fixed-case\">SVC<\/jats:styled-content> over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal decremental responses are well described in <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>. We report that the degree of decremental response does not correlate with the degree of weakness. Abnormal decrement is only rarely present in nerve\u2013muscle pairs with normal motor power. Our findings did not support a correlation between abnormal decrement and clinical measures suggesting that <jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content> may not be useful as a biomarker to monitor <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.846","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T08:50:23Z","timestamp":1506415823000},"source":"Crossref","is-referenced-by-count":9,"title":["Decremental responses in patients with motor neuron disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-8283","authenticated-orcid":false,"given":"Mohammed H.","family":"Alanazy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine King Saud University Medical City and College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janka","family":"Hegedus","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"White","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Korngut","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1107","article-title":"An approach to interpreting spirometry","volume":"69","author":"Barreiro T. 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