{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:52:45Z","timestamp":1773867165528,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFC0909100"],"award-info":[{"award-number":["2017YFC0909100"]}]},{"name":"Jiangsu Provincial Special Program of Medical Science","award":["BL2014042"],"award-info":[{"award-number":["BL2014042"]}]},{"name":"Jiangsu Province\u2019s Young Medical Talents Program","award":["QNRC2016872"],"award-info":[{"award-number":["QNRC2016872"]}]},{"name":"Social development projects in Jiangsu Province","award":["BE2017653"],"award-info":[{"award-number":["BE2017653"]}]},{"name":"Suzhou Clinical Research Center of Neurological Disease","award":["Szzx201503"],"award-info":[{"award-number":["Szzx201503"]}]},{"name":"Suzhou Science and Technology Development Program","award":["SYS201620, SYS201624"],"award-info":[{"award-number":["SYS201620, SYS201624"]}]},{"name":"Jiangsu Provincial Medical Key Discipline Project","award":["ZDXKB2016022"],"award-info":[{"award-number":["ZDXKB2016022"]}]},{"name":"Youth fund of Jiangsu Province\u2019s natural science foundation","award":["BK20170355"],"award-info":[{"award-number":["BK20170355"]}]},{"name":"National Natural Science Pre-Research Foundation of China","award":["SDFEYGJ1605"],"award-info":[{"award-number":["SDFEYGJ1605"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to report and evaluate the associations between serum sodium and chloride and dyskinesia in patients with Parkinson's disease. One hundred and two patients with Parkinson's disease were enrolled in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients\u2019 serum electrolytes including sodium, calcium, potassium, magnesium, and chloride were measured. Other demographic information was collected, and Unified Parkinson's disease rating scale and Hoehn and Yahr stage scale were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with dyskinesia tended to have longer duration of disease, higher daily levodopa\u2010equivalent dose, and Hoehn\u2013Yahr stage, with lower serum sodium than those without dyskinesia. Spearman correlation analyses showed that serum sodium inversely correlated with duration of disease (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.218, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.028), and positively correlated with serum chloride levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.565, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001). Univariate logistic regression analysis found that duration of disease, daily levodopa\u2010equivalent dose, serum sodium, and serum chloride were associated with dyskinesia in Parkinson's disease patients (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05 for all). After adjusting for age, sex, age at onset of Parkinson's disease, medical history, and other covariates, serum sodium and chloride were still associated with dyskinesia, with corresponding Odd ratios 0.783 (95% confidence intervals, 0.642\u20130.955) and 0.796 (95% confidence intervals, 0.652\u20130.972), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicated that serum sodium and chloride levels were inversely associated with dyskinesia in patients with Parkinson's disease. Further studies with large samples and range of serum sodium and chloride are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.867","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T04:52:37Z","timestamp":1510289557000},"source":"Crossref","is-referenced-by-count":19,"title":["Serum sodium and chloride are inversely associated with dyskinesia in Parkinson's disease patients"],"prefix":"10.1002","volume":"7","author":[{"given":"Cheng\u2010jie","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Neurology and Suzhou Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010ke","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Medical College of Soochow University  Suzhou 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