{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:41:57Z","timestamp":1789990917448,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catholic Medical Center Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Gait recovery is an important goal in stroke patients. Several studies have sought to uncover relationships between specific brain lesions and the recovery of gait, but the effects of specific brain lesions on gait remain unclear. Thus, we investigated the effects of stroke lesions on gait recovery in stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In total, 30 subjects with stroke were assessed in a retrograde longitudinal observational study. To assess gait function, the functional ambulation category (\n                      <jats:styled-content style=\"fixed-case\">FAC<\/jats:styled-content>\n                      ) was tested four times: initially (within 2\u00a0weeks) and 1, 3, and 6\u00a0months after the onset of the stroke. Brain lesions were analyzed via overlap, subtraction, and voxel\u2010based lesion symptom mapping (\n                      <jats:styled-content style=\"fixed-case\">VLSM<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ambulation with\n                      <jats:styled-content style=\"fixed-case\">FAC<\/jats:styled-content>\n                      improved significantly with time. Subtraction analysis showed that involvement of the corona radiata, internal capsule, globus pallidus, and putamen were associated with poor recovery of gait throughout 6\u00a0months after onset. The caudate nucleus did influence poor recovery of gait at 6\u00a0months after onset.\n                      <jats:styled-content style=\"fixed-case\">VLSM<\/jats:styled-content>\n                      revealed that corona radiata, internal capsule, globus pallidus, putamen and cingulum were related with poor recovery of gait at 3\u00a0months after onset. Corona radiata, internal capsule, globus pallidus, putamen, primary motor cortex, and caudate nucleus were related with poor recovery of gait at 6\u00a0months after onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results identified several important brain lesions for gait recovery in patients with stroke. These results may be useful for planning rehabilitation strategies for gait and understanding the prognosis of gait in stroke patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.868","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T01:02:39Z","timestamp":1508893359000},"source":"Crossref","is-referenced-by-count":39,"title":["Brain lesions affecting gait recovery in stroke patients"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-1393","authenticated-orcid":false,"given":"Kyoung Bo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-593X","authenticated-orcid":false,"given":"Joon Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-6173","authenticated-orcid":false,"given":"Bo Young","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-8997","authenticated-orcid":false,"given":"Bomi","family":"Sul","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-1075","authenticated-orcid":false,"given":"Seojin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-3631","authenticated-orcid":false,"given":"Won Jin","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-4339","authenticated-orcid":false,"given":"Byong Yong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Yongin University  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-4153","authenticated-orcid":false,"given":"Seong Hoon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine St. Vincent's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,25]]},"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T05:34:55Z","timestamp":1696656895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,25]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/brb3.868"],"URL":"https:\/\/doi.org\/10.1002\/brb3.868","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,25]]},"article-number":"e00868"}}