{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T01:55:51Z","timestamp":1772589351329,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The role of<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 in acute ischemic stroke still remains unclear. This study aims to demonstrate the value of<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 in evaluating degrees of intracranial artery stenosis and to predict prognosis in stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and seventy\u2010two patients were included in this study and basic data were collected within 72\u00a0hr on admission. We assessed the association between<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 levels and stroke conditions in one\u2010year duration. After adjusting for potential confounders, regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 levels were increased significantly in severe patients compared to the mild stroke group (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.011). After adjusting confounders,<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 was associated with a poor functional outcome in patients with an adjusted<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>of 2. 946 (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.788\u20134.856,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). There was also positive correlation between<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 levels and the degrees of intracranial artery stenosis in the different groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 levels could be used to evaluate the severity of stroke and the degrees of intracranial artery stenosis. Furthermore,<jats:styled-content style=\"fixed-case\">sLOX<\/jats:styled-content>\u20101 could be exploited to predict the long\u2010term functional outcome of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.879","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T05:10:02Z","timestamp":1513141802000},"source":"Crossref","is-referenced-by-count":15,"title":["Role of<scp>sLOX<\/scp>\u20101 in intracranial artery stenosis and in predicting long\u2010term prognosis of acute ischemic stroke"],"prefix":"10.1002","volume":"8","author":[{"given":"Xian\u2010Mei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Ping","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-0831","authenticated-orcid":false,"given":"Jie","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Neurology Yangpu Hospital of Tongji University ShangHai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Qian","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng\u2010Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie\u2010Er","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Yi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-3052","authenticated-orcid":false,"given":"Bei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2009.00387.x"},{"key":"e_1_2_8_4_1","first-page":"48","article-title":"Differentiation of serum sLOX\u20101 and NO levels in acute ischemic stroke patients with internal carotid artery stenosis and those without internal carotid artery stenosis","volume":"99","author":"Bns P. 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