{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:06:33Z","timestamp":1792919193348,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Pure sensory neuropathies involving the dorsal root ganglia are commonly referred to as sensory ganglionopathies (SG<\/jats:styled-content>). Causes of SG<\/jats:styled-content> can be inherited (as seen in Friedreich's ataxia) or acquired (e.g. immune\u2010mediated or paraneoplastic). Diagnostic criteria for confirming SG<\/jats:styled-content> have been published and consist of a combination of clinical and neurophysiological parameters. The aim of our study was to develop a neurophysiological method for rapid screening for diagnosis of SG<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>For each subject we obtained the sensory nerve action potentials (SNAP<\/jats:styled-content>s) of five nerves (median, ulnar, radial, sural and superficial peroneal) bilaterally. In the presence of an entrapment neuropathy we obtained the SNAP<\/jats:styled-content> of the medial antebrachial cutaneous nerves bilaterally. We estimated the number of pairs of nerves showing a SNAP<\/jats:styled-content> asymmetry of >50% (difference of SNAP<\/jats:styled-content>s\/ lower SNAP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Sixty\u2010eight subjects, 34 patients with SG<\/jats:styled-content> and 34 age and sex\u2010matched controls, participated in the study. Among all subjects using a receiver operating characteristic (ROC<\/jats:styled-content>) curve analysis, the area under the curve was 0.984 (95% CI<\/jats:styled-content>, 0.960\u20131.000; SE<\/jats:styled-content>, 0.012; p\u00a0<\/jats:italic><\u00a0.001). In order to detect SG<\/jats:styled-content>, presence of SNAP<\/jats:styled-content> asymmetry of >50% in 2 pairs of nerves, not explained by an entrapment neuropathy, shows a sensitivity of 97.1%, a specificity of 94.1%, a positive predictive value of 94.3% and a negative predictive value of 97.0<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The number of pairs of nerves showing a SNAP<\/jats:styled-content> asymmetry of >50% may be used as a novel rapid screening tool of patients with SG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.880","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T06:09:00Z","timestamp":1511503740000},"source":"Crossref","is-referenced-by-count":29,"title":["Rapid neurophysiological screening for sensory ganglionopathy: A novel approach"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-3092","authenticated-orcid":false,"given":"Panagiotis","family":"Zis","sequence":"first","affiliation":[{"name":"Academic Department of Neurosciences Sheffield Teaching Hospitals NHS Foundation Trust Sheffield South Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Hadjivassiliou","sequence":"additional","affiliation":[{"name":"Academic Department of Neurosciences Sheffield Teaching Hospitals NHS Foundation Trust Sheffield South Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ptolemaios Georgios","family":"Sarrigiannis","sequence":"additional","affiliation":[{"name":"Academic Department of Neurosciences Sheffield Teaching Hospitals NHS Foundation Trust Sheffield South Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander St John Edward","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield South Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasappaiah Ganesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Academic Department of Neurosciences Sheffield Teaching Hospitals NHS Foundation Trust Sheffield South Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Practical statistics for medical research","author":"Altman D. G.","year":"1999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051862"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp136"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70333-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20130063"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f25ee0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003632"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23975"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40673-016-0060-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.08.019"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8082-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000180"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:42:48Z","timestamp":1696041768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/brb3.880"],"URL":"https:\/\/doi.org\/10.1002\/brb3.880","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]},"article-number":"e00880"}}