{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:43:22Z","timestamp":1776962602506,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001350","name":"Ministry of Health -Singapore","doi-asserted-by":"publisher","award":["TCMRG 2703001"],"award-info":[{"award-number":["TCMRG 2703001"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Fatigue is a common and disabling problem in patients with Parkinson's disease (PD<\/jats:styled-content>), and there is currently no satisfactory treatment. As acupuncture has been reported to be effective in fatigue related to other conditions, we sought to evaluate its efficacy in PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a single center, randomized, sham\u2010controlled study. Forty PD<\/jats:styled-content> patients with moderately severe fatigue were randomized to receive 5\u00a0weeks of biweekly real or sham acupuncture. The primary outcome was change on the General Fatigue score of the Multidimensional Fatigue Inventory (MFI<\/jats:styled-content>\u2010GF<\/jats:styled-content>) at 5\u00a0weeks. Secondary outcomes included MFI<\/jats:styled-content>\u2010Total score, Unified Parkinson's Disease Rating Scale Motor score (UPDRS<\/jats:styled-content> Motor), Parkinson's Disease Questionnaire\u201039 (PDQ<\/jats:styled-content> 39), Geriatrics Depression Scale (GDS<\/jats:styled-content>), and Epworth Sleepiness Scale ESS<\/jats:styled-content>). All outcome measures were evaluated at baseline, 5 and 9\u00a0weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>Both groups showed significant improvements in MFI<\/jats:styled-content>\u2010GF<\/jats:styled-content> and MFI<\/jats:styled-content>\u2010Total scores at 5 and 9\u00a0weeks, but there were no significant between\u2010group differences. There were no improvements from baseline for PDQ<\/jats:styled-content> 39, GDS<\/jats:styled-content>, and ESS<\/jats:styled-content>. Although improvements were noted for the UPDRS<\/jats:styled-content> Motor score in the real acupuncture group, no between\u2010group difference could be demonstrated.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Both real and sham acupuncture are equally effective in improving PD<\/jats:styled-content>\u2010related fatigue, and it is likely that this is due to nonspecific or placebo effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.897","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T09:12:36Z","timestamp":1514538756000},"source":"Crossref","is-referenced-by-count":41,"title":["Acupuncture in the treatment of fatigue in Parkinson's disease: A pilot, randomized, controlled, study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-0093","authenticated-orcid":false,"given":"Keng H.","family":"Kong","sequence":"first","affiliation":[{"name":"Complementary Integrative Medicine Tan Tock Seng Hospital Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwee L.","family":"Ng","sequence":"additional","affiliation":[{"name":"Neurology, National Neuroscience Institute Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Neurology, National Neuroscience Institute Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora W.","family":"Ng","sequence":"additional","affiliation":[{"name":"Complementary Integrative Medicine Tan Tock Seng Hospital Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siang I.","family":"Tan","sequence":"additional","affiliation":[{"name":"Complementary Integrative Medicine Tan Tock Seng Hospital Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay Y.","family":"Tay","sequence":"additional","affiliation":[{"name":"Neurology, National Neuroscience Institute Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing L.","family":"Au","sequence":"additional","affiliation":[{"name":"Neurology, National Neuroscience Institute Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis C. 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