{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:09:18Z","timestamp":1790356158879,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Subjective chronic tinnitus is a common medical syndrome with a high frequency of cognitive impairment; however, the characteristics of cognitive impairment in chronic tinnitus are poorly understood. Investigating the scope of cognitive impairment across the severity spectrum of tinnitus patients may shed light on the issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A consecutive series of 207 subjective chronic tinnitus patients were classified into mild tinnitus group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a095) and severe tinnitus group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0112) by THI score (the cutoff THI scores were 37\/38). These patients were assessed using the Cognitive Abilities Screening Instrument (CASI) and P300 event\u2010related potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although pure tone averages were not different between mild or severe tinnitus patients, severe tinnitus patients scored lower on the CASI assessment as well as almost all subdomains of CASI, particularly in items such as \u201cshort\u2010term memory,\u201d \u201cconcentration or mental manipulation,\u201d \u201corientation,\u201d \u201cabstraction and judgment,\u201d \u201clanguage abilities,\u201d and \u201cvisual construction.\u201d Furthermore, compared to mild tinnitus patients, severe tinnitus patients exhibited longer N2 and P3 latencies. Finally, a correlation analysis revealed that tinnitus severity was negatively correlated with CASI score and positively correlated with N2 and P3 latencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals that tinnitus patients on the severe end of the spectrum may be at risk for serious cognitive deficits, which may not be a secondary response to disease manifestations but a primary feature of the underlying disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.918","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T11:12:44Z","timestamp":1517397164000},"source":"Crossref","is-referenced-by-count":57,"title":["The characteristics of cognitive impairment in subjective chronic 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