{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:48:44Z","timestamp":1776692924471,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation for Young Scholars of China","award":["81500968"],"award-info":[{"award-number":["81500968"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To investigate the cause of the motor asymmetry in Wilson's disease (WD<\/jats:styled-content>) patients using functional MRI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifty patients with WD<\/jats:styled-content> and 20 age\u2010matched healthy controls were enrolled. Neurological symptoms were scored using the modified Young Scale. All study subjects underwent diffusion tensor imaging (DTI<\/jats:styled-content>), susceptibility\u2010weighted imaging (SWI<\/jats:styled-content>), and resting\u2010state functional MRI<\/jats:styled-content> (rs\u2010fMRI<\/jats:styled-content>) of the brain. Six regions of interest (ROI<\/jats:styled-content>) were chosen. Fiber volumes between ROI<\/jats:styled-content>s on DTI<\/jats:styled-content>, corrected phase (CP<\/jats:styled-content>) values on SWI<\/jats:styled-content>, amplitude of low\u2010frequency fluctuation (ALFF<\/jats:styled-content>), and regional homogeneity (REHO<\/jats:styled-content>) values on rs\u2010fMRI<\/jats:styled-content> were determined. Asymmetry index (right or left value\/left or right value) was evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Asymmetry of rigidity, tremor, choreic movement, and gait abnormality (asymmetry index\u00a0=\u00a01.33, 1.39, 1.36, 1.40), fiber tracts between the GP<\/jats:styled-content> and substantia nigra (SN<\/jats:styled-content>), GP<\/jats:styled-content> and PU<\/jats:styled-content>, SN<\/jats:styled-content> and thalamus (TH<\/jats:styled-content>), SN<\/jats:styled-content> and cerebellum, head of the caudate nucleus (CA<\/jats:styled-content>) and SN<\/jats:styled-content>, PU<\/jats:styled-content> and CA<\/jats:styled-content>, CA<\/jats:styled-content> and TH<\/jats:styled-content>, TH<\/jats:styled-content> and cerebellum (asymmetry index\u00a0=\u00a01.233, 1.260, 1.269, 1.437, 1.503, 1.138, 1.145, 1.279), CP<\/jats:styled-content> values in the TH<\/jats:styled-content>, SN<\/jats:styled-content> (asymmetry index\u00a0=\u00a01.327, 1.166), ALFF<\/jats:styled-content> values, and REHO<\/jats:styled-content> values of the TH<\/jats:styled-content> (asymmetry index\u00a0=\u00a01.192, 1.233) were found. Positive correlation between asymmetry index of rigidity and fiber volumes between the GP<\/jats:styled-content> and SN<\/jats:styled-content>, SN<\/jats:styled-content> and TH<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a0.221, .133, p<\/jats:italic>\u00a0=\u00a0.043, .036), and tremor and fiber volumes between the CA<\/jats:styled-content> and TH<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a0.045, p<\/jats:italic>\u00a0=\u00a0.040) was found.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The neurological symptoms of patients with WD<\/jats:styled-content> were asymmetry. The asymmetry of fiber projections may be the main cause of motor asymmetry in patients with WD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.930","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T11:29:12Z","timestamp":1523705352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The asymmetry of neural symptoms in Wilson's disease patients detecting by diffusion tensor imaging, resting\u2010state functional MRI<\/scp>, and susceptibility\u2010weighted imaging"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6583-9734","authenticated-orcid":false,"given":"Xiang\u2010xue","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology The East Area of the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou 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