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This study investigated the effect of age on thalamo\u2010cortical and thalamo\u2010hippocampal functional connectivity (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) and the association between thalamic <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and visual\u2013spatial memory and reaction time (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) performance in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting\u2010state functional magnetic resonance images were obtained from younger (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and older (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) adults. A seed\u2010based approach was used to assess the <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> between the thalamus and (1) sensory resting\u2010state networks; (2) the hippocampus. Participants also completed visual\u2013spatial memory and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> tasks, from the Cambridge Neuropsychological Test Automated Battery (<jats:styled-content style=\"fixed-case\">CANTAB<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older adults exhibited a loss of specificity in the <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> between sensory thalamic subregions and corresponding sensory cortex. Greater thalamo\u2010motor <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> in older adults was associated with faster <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>s. Furthermore, older adults exhibited greater thalamo\u2010hippocampal <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> compared to younger adults, which was greatest for those with the poorest visual\u2013spatial memory performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although older adults exhibited poorer visual\u2013spatial memory and slower reaction times compared to younger adults, \u201cgood\u201d and \u201cpoorer\u201d older performers exhibited different patterns of thalamo\u2010cortical and thalamo\u2010hippocampal <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>. These results highlight the potential role of thalamic connectivity in supporting reaction times and memory in aging. 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