{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:36:47Z","timestamp":1780580207524,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007350","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["FOMIX\u2010QRO QRO\u20102014\u2010C03\u2010250289"],"award-info":[{"award-number":["FOMIX\u2010QRO QRO\u20102014\u2010C03\u2010250289"]}],"id":[{"id":"10.13039\/501100007350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Major depressive disorders are characterized by their severity and long\u2010lasting symptoms, which make such disorders highly disabling illnesses. Unfortunately, 50% of major depressive patients experience relapses, perhaps partly because drug research has been performed only in animal models that screen for antidepressant drugs that appear to only ameliorate acute depression symptoms. The bilateral olfactory bulbectomy (<jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content>) animal model presents the advantage of mimicking the symptoms of chronic depression by means of brain surgery. Adenosine purinergic receptors A2A (A2<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) have been the target of interest in the field of psychiatric diseases. This study aimed to show which A2A receptor ligands exert antidepressive\u2010like effects in the <jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content> rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty Sprague\u2010Dawley male rats were divided into four groups: control, <jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content>\u00a0+\u00a0vehicle, <jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">ZM<\/jats:styled-content> 241385, and <jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content>\u00a0+\u00a0adenosine groups. Pharmacological treatment was administered for 14\u00a0days, and the rats were examined via the forced swim test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>), open field test (<jats:styled-content style=\"fixed-case\">OFT<\/jats:styled-content>), and sucrose preference test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">ZM<\/jats:styled-content> 241385 group exhibited decreased immobility time in the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>, decreased isolation time in the <jats:styled-content style=\"fixed-case\">OFT<\/jats:styled-content>, and reversed anhedonia behavior in the <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> compared to the vehicle group. However, no significant differences for adenosine treatment were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ZM<\/jats:styled-content> 241385 administration (2\u00a0mg\/kg i.p.) restored behavioral changes associated with <jats:styled-content style=\"fixed-case\">OBX<\/jats:styled-content>\u2010induced depression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.952","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T05:16:07Z","timestamp":1524028567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy"],"prefix":"10.1002","volume":"8","author":[{"given":"Karla Margarita","family":"Padilla","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Quer\u00e9taro Centro Universitario  Quer\u00e9taro M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Quintanar\u2010Setephano","sequence":"additional","affiliation":[{"name":"Centro de Ciencias B\u00e1sicas Departamento de Fisiolog\u00eda y Farmacolog\u00eda Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"L\u00f3pez\u2010Vallejo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Departamento de Qu\u00edmica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Cristina","family":"Berumen","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Quer\u00e9taro Centro Universitario  Quer\u00e9taro M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Miledi","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico  Juriquilla Quer\u00e9taro M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-344X","authenticated-orcid":false,"given":"Guadalupe","family":"Garc\u00eda\u2010Alcocer","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Quer\u00e9taro Centro Universitario  Quer\u00e9taro M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1098"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000106"},{"key":"e_1_2_8_5_1","first-page":"897","article-title":"Pharmacological and combined interventions for the acute depressive episode: Focus on efficacy and tolerability","volume":"5","author":"Brunoni A. 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