{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:23:27Z","timestamp":1793294607641,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is widely used in several muscle disorders. Diffusion\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) is used to quantify the random motion of water molecules. Electromyography (<jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content>) is a clinically used diagnostic tool in myositis. The aim of this study was to elucidate possible associations between <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values and <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> findings in myositis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Seven patients (eight investigated muscles) with myositis (mean age 51.43\u00a0\u00b1\u00a019\u00a0years) were included in this study. The diagnosis was confirmed by histopathology in every case. <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> was obtained with a 1.5\u2010T scanner using two b\u2010values 0 and 1000\u00a0s\/mm\u00b2. In all patients, a needle electromyography (<jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content>) was performed within 3\u00a0days to the <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. The following <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> parameters were studied: motor unit action potential (<jats:styled-content style=\"fixed-case\">MUAP<\/jats:styled-content>) amplitudes and durations, as well as pathological spontaneous activity. Spearman's correlation coefficient was used to analyze associations between investigated parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated mean <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>mean<\/jats:sub> value was 1.51\u00a0\u00b1\u00a00.29\u00a0\u00d7\u00a010<jats:sup>\u22123\u00a0<\/jats:sup>mm\u00b2\/s, mean <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>min<\/jats:sub> was 1.28\u00a0\u00b1\u00a00.27\u00a0\u00d7\u00a010<jats:sup>\u22123\u00a0<\/jats:sup>mm\u00b2\/s, and mean <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>max<\/jats:sub> was 1.73\u00a0\u00b1\u00a00.28\u00a0\u00d7\u00a010<jats:sup>\u22123\u00a0<\/jats:sup>mm\u00b2\/s. Correlation analysis identified significant associations between <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>mean<\/jats:sub> and duration of the <jats:styled-content style=\"fixed-case\">MUAP<\/jats:styled-content> (p<jats:italic>\u00a0<\/jats:italic>=\u00a0.78 P\u00a0=\u00a0.0279) and between <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>min<\/jats:sub> and duration of the <jats:styled-content style=\"fixed-case\">MUAP<\/jats:styled-content> (p\u00a0=\u00a0.85, P\u00a0=\u00a0.01). There were no significant differences according to pathological spontaneous activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>mean<\/jats:sub> and <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><jats:sub>min<\/jats:sub> showed strong positive correlations with the duration of the <jats:styled-content style=\"fixed-case\">MUAP<\/jats:styled-content> in myositis patients. Both modalities might similarly reflect muscle fiber loss in myositis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.958","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:41:17Z","timestamp":1522456877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations between apparent diffusion coefficient and electromyography parameters in myositis\u2014A preliminary study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-706X","authenticated-orcid":false,"given":"Hans\u2010Jonas","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Emmer","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther University 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