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This study aimed to investigate the effects of CBT<\/jats:styled-content> on changes in the intrinsic whole\u2010brain functional network of OCD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Twenty drug\u2010naive and noncomorbid OCD<\/jats:styled-content> patients were recruited, and resting\u2010state functional magnetic resonance imaging was performed before and after 12\u00a0weeks of CBT<\/jats:styled-content>. Moreover, 20 healthy controls were scanned twice with a 12\u2010week interval. A graph\u2010theory degree centrality (DC<\/jats:styled-content>) approach and functional connectivity method were used to analyze the whole\u2010brain functional network hub and connectivity changes in OCD<\/jats:styled-content> patients before and after CBT<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>A significant group\u00a0\u00d7\u00a0time interaction on DC<\/jats:styled-content> was found in the left dorsolateral prefrontal cortex (DLPFC<\/jats:styled-content>); the DC<\/jats:styled-content> in the left DLPFC<\/jats:styled-content> was significantly reduced after CBT<\/jats:styled-content> treatment. Resting\u2010state functional connectivity (RSFC<\/jats:styled-content>) between the left DLPFC<\/jats:styled-content> and right orbitofrontal cortex was increased in the OCD<\/jats:styled-content> patients at baseline, and normalized after CBT<\/jats:styled-content> treatment. RSFC<\/jats:styled-content> changes between the left DLPFC<\/jats:styled-content> and default mode network (DMN<\/jats:styled-content>) positively correlated with changes in clinical symptoms in OCD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These findings suggest that CBT<\/jats:styled-content> can modulate changes in intrinsic functional network hubs in the cortico\u2013striato\u2013thalamo\u2010cortical circuit in OCD<\/jats:styled-content> patients. Cognitive control network and DMN<\/jats:styled-content> connectivity may be a potential imaging biomarker for evaluating CBT<\/jats:styled-content> treatment for OCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.963","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:37:11Z","timestamp":1523939831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The effects of cognitive behavioral therapy on resting\u2010state functional brain network in drug\u2010naive patients with obsessive\u2013compulsive disorder"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-3091","authenticated-orcid":false,"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University Qiqihar Heilongjiang 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