{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:47:53Z","timestamp":1787510873691,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ES 434\/8\u20101"],"award-info":[{"award-number":["ES 434\/8\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n \n Gait impairment and reduced mobility are typical features of idiopathic Parkinson's disease (\n iPD<\/jats:styled-content>\n ) and atypical parkinsonian disorders (\n APD<\/jats:styled-content>\n ). Quantitative gait assessment may have value in the diagnostic workup of parkinsonian patients and as endpoint in clinical trials. The study aimed to identify quantitative gait parameter differences in\n iPD<\/jats:styled-content>\n and\n APD<\/jats:styled-content>\n patients using sensor\u2010based gait analysis and to correlate gait parameters with clinical rating scales.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n \n Patients with\n iPD<\/jats:styled-content>\n and\n APD<\/jats:styled-content>\n including Parkinson variant multiple system atrophy and progressive supranuclear palsy matched for age, gender, and Hoehn and Yahr (\u22643) were recruited at two Movement Disorder Units and assessed using standardized clinical rating scales (\n MDS<\/jats:styled-content>\n \u2010\n UPDRS<\/jats:styled-content>\n \u20103,\n UMSARS<\/jats:styled-content>\n ,\n PSP\u2010RS<\/jats:styled-content>\n ). Gait analysis consisted of inertial sensor units laterally attached to shoes, generating as objective targets spatiotemporal gait parameters from 4\u00a0\u00d7\u00a010\u00a0m walk tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Objective sensor\u2010based gait analysis showed that gait speed and stride length were markedly reduced in\n APD<\/jats:styled-content>\n compared to\n iPD<\/jats:styled-content>\n patients. Moreover, clinical ratings significantly correlated with gait speed and stride length in\n APD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our findings suggest that patients with\n APD<\/jats:styled-content>\n had more severely impaired gait parameters than\n iPD<\/jats:styled-content>\n patients despite similar disease severity. Instrumented gait analysis provides complementary rater independent, quantitative parameters that can be exploited for clinical trials and care.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.977","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T08:43:07Z","timestamp":1525682587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Sensor\u2010based gait analysis in atypical parkinsonian disorders"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-2860","authenticated-orcid":false,"given":"Cecilia","family":"Raccagni","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Ga\u00dfner","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology University Hospital Erlangen Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Eschlboeck","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Boesch","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Krismer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seppi","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck Innsbruck 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