{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:38:38Z","timestamp":1791229118144,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Facial onset motor and sensory neuronopathy (<jats:styled-content style=\"fixed-case\">FOSMN<\/jats:styled-content>) is a rare disease whose cardinal features are initial asymmetrical facial sensory deficits followed by bulbar symptoms and spreading of sensory and motor deficits from face to scalp, neck, upper trunk, and upper extremities in a rostral\u2013caudal direction. Although bulbar involvement is frequently observed in <jats:styled-content style=\"fixed-case\">FOSMN<\/jats:styled-content>, dysphagia in these patients has not been fully described. In this study, we aimed to characterize dysphagia as a prognostic factor in <jats:styled-content style=\"fixed-case\">FOSMN<\/jats:styled-content> by investigating our institutional case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records, including swallowing function tests, of six patients with <jats:styled-content style=\"fixed-case\">FOSMN<\/jats:styled-content> (three men and three women) who were thoroughly examined at Kyushu University Hospital between 1 January 2005 and 30 November 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average age at onset was 58.5\u00a0years; average disease duration was 5.7\u00a0years. All patients developed bulbar dysfunction and dysphagia (at an average of 1.8 and 2.6\u00a0years from onset, respectively), resulting in choking episodes in three patients, percutaneous endoscopic gastrostomy placement in three, and recurrent aspiration pneumonia in one. Four of five patients evaluated with videofluoroscopic swallowing studies had poor oral retention, leading to bolus flowing into the pharynx before swallowing; the fifth patient showed poor lingual transfer. Fiberoptic endoscopic evaluation of swallowing revealed leakage of blue\u2010dyed water from the mouth to the pharynx in three patients because of poor oral retention, but only mild pharyngeal phase dysphagia in all four cases evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral phase dysphagia predominates in the early stage of <jats:styled-content style=\"fixed-case\">FOSMN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.999","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T08:07:08Z","timestamp":1526890028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral phase dysphagia in facial onset sensory and motor neuronopathy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-623X","authenticated-orcid":false,"given":"Mitsuru","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Isobe","sequence":"additional","affiliation":[{"name":"Department of 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