{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:19:38Z","timestamp":1783012778151,"version":"3.54.6"},"reference-count":229,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biological Reviews"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Species from octopi to humans engage in play. This review examines how epigenetic mechanisms, such as DNA methylation, may regulate play behaviour across taxa. We frame play through historical definitions, categorizing it into object, locomotor, and social forms, and examine how each may be linked to epigenetic shifts, for example in brain\u2010derived neurotrophic factor (BDNF) expression. We then explore the role of domestication in enhancing play\n                    <jats:italic>via<\/jats:italic>\n                    methylation of stress and sociality genes, comparing domesticated chickens, dogs, and foxes to their wild kin. We link the neurobiology of play, spanning the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis and reward circuits, to epigenetic modulation. Assessing the evolutionary fitness advantages of play, we compare adaptive benefits against the surplus resource theory. Despite its presence in many taxa, there remains limited direct evidence for a role of epigenetic mechanisms in play, and we urge research into the developmental and adaptive roles of play across a wider range of species.\n                  <\/jats:p>","DOI":"10.1002\/brv.70142","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:54:01Z","timestamp":1770123241000},"page":"1683-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methylation and merriment: an exploration of epigenetic mechanisms underlying play behaviour"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4142-6234","authenticated-orcid":false,"given":"Robert J.","family":"Malka","sequence":"first","affiliation":[{"name":"Independent Researcher  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Arranz","sequence":"additional","affiliation":[{"name":"UCLA  Los Angeles CA 90095 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-4690","authenticated-orcid":false,"given":"Ignacio","family":"Baselga\u2010Carretero","sequence":"additional","affiliation":[{"name":"UCLA  Los Angeles CA 90095 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fetho.2024.1458136"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3272-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2945-14.2015"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.212"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105319"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2016.10.023"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.200141"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0610-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.06.017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2009.01871.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.47"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83856-9"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511608575"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017617"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.09.029"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711-018-0384-z"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a109263"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2018.10.002"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500451"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0524-22.2022"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad212"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1591(96)01087-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.46.2.192"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.040485.115"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.012"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0100-2"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.08.052"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00216"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03599.x"},{"key":"e_1_2_12_33_1","first-page":"5","volume-title":"Play in Animals and Humans","author":"Burghardt G. M.","year":"1984"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/3229.001.0001"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.12966\/abc.05.01.2014"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2020.02.010"},{"key":"e_1_2_12_37_1","volume-title":"Play in Fowl and Flies: The Renaissance Continues","author":"Burghardt G. M.","year":"2025"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/21594937.2025.2464320"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/eth.12312"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9280.00217"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/21594937.2022.2152183"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105617"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2361(1996)15:3<223::AID-ZOO3>3.0.CO;2-D"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2008.07.009"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127815"},{"key":"e_1_2_12_46_1","first-page":"1","volume-title":"Advances in the Study of Behavior","author":"Caro T. M.","year":"1980"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(87)80238-5"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpnec.2021.100107"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.008"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0526-08.2008"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221224598"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1119"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-011-0379-4"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12555"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-devpsych-070120-014806"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13081371"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.22268"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.019"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4425-15.2016"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1163\/156853903322589650"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.12966\/abc.02.04.2015"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0019"},{"key":"e_1_2_12_63_1","first-page":"843","article-title":"Oxytocin, vasopressin, and the neurogenetics of sociality","volume":"9","author":"Donaldson Z. R.","year":"2008","journal-title":"Nature Reviews Neuroscience"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12052-018-0090-x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12131684"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2642"},{"key":"e_1_2_12_67_1","volume-title":"Animal Play Behavior","author":"Fagen R.","year":"1981"},{"key":"e_1_2_12_68_1","first-page":"89","article-title":"Juvenile survival and benefits of play behaviour in brown bears, Ursus arctos","volume":"6","author":"Fagen R.","year":"2004","journal-title":"Evolutionary Ecology Research"},{"key":"e_1_2_12_69_1","first-page":"1053","article-title":"Play behaviour and multi\u2010year juvenile survival in free\u2010ranging brown bears, Ursus arctos","volume":"11","author":"Fagen R.","year":"2009","journal-title":"Evolutionary Ecology Research"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05919"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2003.12.014"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2015.12.008"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05772"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004016"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000430"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2022.08.013"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3695"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.09.013"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1979.0086"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.53.3-4.279"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14101"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12182"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-012-0902-8"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444015"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511608575.003"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2011.01.007"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.09.061"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0032187"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0036104"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-020-01310-1"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(98)00116-8"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.12966\/abc.05.08.2014"},{"key":"e_1_2_12_93_1","volume-title":"Homo Ludens: A Study of the Play\u2010Element in Culture","author":"Huizinga J.","year":"1938"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/379249a0"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911143106"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.70009"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1086\/598822"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1089"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13480"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/09575146.2019.1619670"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2025.106582"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394586-0.00002-0"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0594"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2632"},{"key":"e_1_2_12_105_1","first-page":"1808","article-title":"Non\u2010coding RNAs in neurodevelopmental disorders\u2010from diagnostic biomarkers to therapeutic targets: a systematic review","volume":"13","author":"Karaivazoglou K.","year":"2025","journal-title":"Biomedicine"},{"key":"e_1_2_12_106_1","first-page":"eabb9116","article-title":"Paternal deprivation impairs social behavior putatively via epigenetic modification to lateral septum vasopressin receptor. Science","volume":"6","author":"Kelly A. M.","year":"2020","journal-title":"Advances"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.024"},{"key":"e_1_2_12_108_1","first-page":"805","article-title":"Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques","volume":"9","author":"Kinnally E. L.","year":"2010","journal-title":"Genes, Brain and Behavior"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.034116"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12552"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.06.002"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.12966\/abc.05.03.2014"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-018-0611-6"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1998.1493"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1345-08.2008"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20775"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1080\/21594937.2022.2152184"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144750"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.013"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20462"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.03.002"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2019.10.011"},{"key":"e_1_2_12_123_1","first-page":"13817","article-title":"Play ontogeny in young chickens is affected by domestication and early stress","volume":"12","author":"Lund\u00e9n G.","year":"2022","journal-title":"Scientific Reports"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.97.2.99"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.22"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00073"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmammal\/gyx049"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(85)80073-7"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.113.3.333"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.022"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz127"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.112"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2015.06.008"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03070.x"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jveb.2015.03.002"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2024.02.071"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21203"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516016112"},{"key":"e_1_2_12_139_1","volume-title":"The Oxford Handbook of the Development of Play","author":"Nathan P.","year":"2012"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096376"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-59"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21176"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197212"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105099"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.042739.116"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqae046"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2024.0607"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fetho.2024.1392378"},{"key":"e_1_2_12_149_1","first-page":"159","article-title":"Flipper stroking play behavior in bottlenose dolphins (Tursiops truncatus)","volume":"26","author":"Pace D. S.","year":"2000","journal-title":"Aquatic Mammals"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105124"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052767"},{"key":"e_1_2_12_152_1","first-page":"259","volume-title":"The Routledge International Handbook of Comparative Psychology","author":"Palagi E.","year":"2023"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0215-6"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-86770-w"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195367324.001.0001"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1037\/0000011-034"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.102.5.760"},{"key":"e_1_2_12_158_1","first-page":"278","article-title":"The function of play in the development of the social brain","volume":"3","author":"Pellis S. M.","year":"2010","journal-title":"American Journal of Play"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-47829-6_1085-1"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113196"},{"key":"e_1_2_12_161_1","volume-title":"Play, Dreams, and Imitation in Childhood","author":"Piaget J.","year":"1962"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0078-24.2024"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-07353-3"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316940111"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20412"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2017.0051"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-012-0538-2"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00009-X"},{"key":"e_1_2_12_169_1","first-page":"236","article-title":"Acute stress affects the global DNA methylation profile in rat brain: modulation by physical exercise","volume":"286","author":"Rodrigues G. M.","year":"2015","journal-title":"Behavioural Brain Research"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12614"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.01.043"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113477"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100355"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.1025494"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X12001100"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1080\/15289168.2020.1755084"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20287-3"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109395"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1080\/21594937.2020.1720139"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2004.11.011"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2004.08.025"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.105445"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1163\/1568539X-00003349"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.13730"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/arz090"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1086\/393866"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0218"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1086\/204757"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903964106"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028128"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/47412"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.12.100"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240787"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.023"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.10.009"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-4788-1_21"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120592"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5492-10.2011"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0114-12.2012"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.03.551880"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200800070"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1659"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72730-z"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-29901-3_11"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.83"},{"key":"e_1_2_12_206_1","first-page":"1181","article-title":"Cellular activation in limbic brain systems during social play behaviour in rats","volume":"219","author":"Van Kerkhof L. W. M.","year":"2014","journal-title":"Brain Structure and Function"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.025"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.10"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.12.002"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.10.017"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13519"},{"key":"e_1_2_12_212_1","first-page":"183","article-title":"Peripheral blood mononuclear cell oxytocin and vasopressin receptor expression positively correlates with social and behavioral function in children with autism","volume":"13","author":"Voinsky I.","year":"2019","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_12_213_1","first-page":"622","article-title":"Changes in the rearing environment cause reorganization of molecular networks associated with DNA methylation","volume":"92","author":"Holdt B. M.","year":"2022","journal-title":"Journal of Animal Ecology"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1700398"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.2753\/RPO1061-040505036"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803081105"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.05.031"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800889115"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1276"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7197-5_3"},{"key":"e_1_2_12_221_1","volume-title":"From Wolf to Dog: Behavioural Evolution during Domestication","author":"Wheat C. H.","year":"2018"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2023.104973"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.70020"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.114.165423"},{"key":"e_1_2_12_225_1","volume-title":"Sociobiology","author":"Wilson E. O.","year":"1975"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11060724"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10648-021-09608-7"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.3389\/fetho.2024.1403082"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02748-x"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12662"}],"container-title":["Biological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brv.70142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brv.70142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brv.70142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:38:13Z","timestamp":1783010293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brv.70142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":229,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/brv.70142"],"URL":"https:\/\/doi.org\/10.1002\/brv.70142","archive":["Portico"],"relation":{},"ISSN":["1464-7931","1469-185X"],"issn-type":[{"value":"1464-7931","type":"print"},{"value":"1469-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}