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This review examines how intrinsic and extrinsic factors may influence the successful transmission of filarial nematodes in tick vectors, drawing insights from extensively studied haematophagous dipteran vector systems. We explore how different tick life stages contribute to potential nematode transmission to the host and the influence of abiotic factors on nematode survival and development within ticks. Understanding nematode life stage periodicity and enhancement phenomena in tick\u2010borne filarial systems is equally important for determining transmission dynamics and co\u2010infection patterns. Also important to nematode transmission are vertebrate host movement and tick feeding patterns, which create opportunities for parasite exchange across ecological environments. Knowledge gaps include the physical and molecular mechanisms of transmission, the potential influence of tick genetic variation on vector competence, immune responses across different tick\u2013filarial associations, and epidemiological studies of host and tick patterns of nematode infection. Comprehensive empirical data are also needed to model transmission patterns, including temperature and humidity thresholds for nematode development and survival, field\u2010based tick infection rates, and how tick immune responses affect these processes. Understanding these factors requires integrating expertise from multiple disciplines and adopting an ecosystem\u2010based perspective that considers the interconnected nature of vertebrate hosts, vectors, and environment in the transmission of filarial nematodes.<\/jats:p>","DOI":"10.1002\/brv.70146","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:51:03Z","timestamp":1770886263000},"page":"1779-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Host, vector, and parasite dynamics: exploring intrinsic and extrinsic factors shaping tick\u2010borne filarial nematode transmission"],"prefix":"10.1002","volume":"101","author":[{"given":"Oluwaseun D.","family":"Ajileye","sequence":"first","affiliation":[{"name":"Ecology and Evolutionary Biology Program Texas A&amp;M University  College Station TX 77843 USA"},{"name":"Department of Ecology and Conservation Biology Texas A&amp;M 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