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This review emphasises the essential function of extracellular vesicles (EVs) within this communication network. Tumour\u2010derived EVs (TEVs) not only induce epithelial\u2013mesenchymal transition (EMT) by reprogramming breast cancer cell gene expression networks, thereby enhancing migratory and invasive capabilities, but also serve as a \u2018vanguard\u2019, arriving in the lungs in advance to educate stromal cells and establish a pre\u2010metastatic niche that facilitates breast cancer progression. This review uniquely conceptualises EV\u2010mediated EMT and niche formation as a synergistic and sequential biological continuum. We comprehensively examine the sorting mechanisms of EV molecular cargo, targeted delivery approaches, and hierarchical regulatory networks. Critically, we propose that the concurrent regulation of EMT and niche formation is likely driven by the synergistic action of distinct EV subpopulations rather than single \u2018multitasking\u2019 vesicles. Future investigations dissecting this heterogeneity will be pivotal for verifying this synergistic subpopulations hypothesis and establishing a theoretical basis for precise EV\u2010based metastasis intervention strategies.<\/jats:p>","DOI":"10.1002\/brv.70167","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:00:41Z","timestamp":1775113241000},"page":"2103-2118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial\u2013mesenchymal transition and pulmonary niche formation of breast cancer"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-2490","authenticated-orcid":false,"given":"Jian","family":"Lu","sequence":"first","affiliation":[{"name":"International Oncology Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, 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