{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:50Z","timestamp":1791260810506,"version":"4.1.0"},"reference-count":196,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biological Reviews"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumour cell dormancy is a reversible, non\u2010proliferative state in which cancer cells arrest in the G0 phase of the cell cycle. Increasingly recognized as a critical survival strategy, dormancy enables cancer cells to withstand therapeutic insult, escape immune surveillance, and endure hostile microenvironments. Clinically, dormant cells underlie extended asymptomatic intervals following primary treatment and are notably implicated in estrogen receptor\u2010positive (ER\n                    <jats:sup>+<\/jats:sup>\n                    ) breast cancer, prostate cancer, and clear cell renal cell carcinoma. In this review, we synthesize recent insights into hypoxia\u2010mediated dormancy and, using breast cancer bone metastasis as an archetypal model, delineate how spatiotemporally heterogeneous hypoxia shapes the metastatic cascade. Specifically, we show that graded hypoxia in the primary tumour initiates dormancy traits, while persistent hypoxia within metastatic niches \u2013 such as the bone marrow \u2013 reinforces and deepens quiescence. These transitions are orchestrated by stage\u2010specific activation of hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1) and its dynamic transcriptional outputs. We further argue that a mechanistic understanding of dormancy requires integrative frameworks that bridge single\u2010cell level regulatory programs \u2013 including cell\u2010cycle arrest, translational inhibition, and metabolic reprogramming \u2013 with systems\u2010level networks capturing the dynamic, multistage nature of metastasis. Such integration may uncover actionable vulnerabilities within dormant cell populations and guide the development of precision therapies targeting minimal residual disease.\n                  <\/jats:p>","DOI":"10.1002\/brv.70195","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:39:52Z","timestamp":1782171592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic molecular networks unveil the mechanism behind hypoxia\u2010induced tumour cell dormancy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8945-2966","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"first","affiliation":[{"name":"School of Science, Key Laboratory of High Performance Scientific Computation Xihua University  Chengdu 610039 China"},{"name":"Kuang Yaming Honors School, Nanjing University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Science, Key Laboratory of High Performance Scientific Computation Xihua University  Chengdu 610039 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Shun","family":"Lan","sequence":"additional","affiliation":[{"name":"School of Science, Key Laboratory of High Performance Scientific Computation Xihua University  Chengdu 610039 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Gang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Science, Key Laboratory of High Performance Scientific Computation Xihua University  Chengdu 610039 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan Fu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Science, Key Laboratory of High Performance Scientific Computation Xihua University  Chengdu 610039 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Kuang Yaming Honors School, Nanjing University  Nanjing 210023 China"},{"name":"Institute of Brain Sciences, Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Brain Sciences, Nanjing University  Nanjing 210093 China"},{"name":"National Laboratory of Solid State Microstructures and Department of Physics Nanjing University  Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ccell.2023.12.017","article-title":"Immune evasion by dormant disseminated cancer cells: a Fermi paradox?","volume":"42","author":"Adam\u2010Artigues A.","year":"2024","journal-title":"Cancer Cell"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1091\/mbc.12.4.863","article-title":"Urokinase receptor and fibronectin regulate the ERKMAPK to p38MAPK activity ratios that determine carcinoma cell proliferation or dormancy in vivo","volume":"12","author":"Aguirre\u2010Ghiso J. 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