{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:58:49Z","timestamp":1782964729413,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alzheimer's &amp;amp; Dementia: Behavior &amp;amp; Socioeconomics of Aging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      We investigated the interaction between alcohol use behavior and apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 on cognitive domains among non\u2010Hispanic Black (NHB), Hispanic, and non\u2010Hispanic White (NHW) individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the Health and Aging Brain Study\u2013Health Disparities data, we analyzed 2143 adults aged 50+ using linear regression analysis with interaction between alcohol use and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 on cognitive domains, stratified into NHB (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0549), Hispanic (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0679), and NHW (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0915) groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cognitive performance was negatively associated with alcohol use among\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers, and this association was stronger in individuals with two \u03b54 alleles, indicating a dose\u2010dependent effect. Such interaction was observed for executive function and episodic memory among NHB participants, and episodic memory and language among NHW participants. No significant interactions were observed among Hispanic participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 significantly moderated the association between alcohol use and cognitive performance of various racial\/ethnic groups with a dose\u2013response relationship.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bsa3.70077","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:04:56Z","timestamp":1776222296000},"source":"Crossref","is-referenced-by-count":0,"title":["Alcohol use and\n                    <i>APOE<\/i>\n                    \u03b54 interaction with cognitive domains among American adults from diverse racial\/ethnic groups: A HABS\u2010HD 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