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The cumulative impact on cardiometabolic risk factors and cognitive and neuroimaging outcomes is not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed data from 460 NHB men. Cumulative SDoH index spanning multiple domains was examined both categorically and continuously. Regression models were performed to estimate associations of cumulative SDoH index with cardiometabolic risk factors, cognitive performance, and neuroimaging biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher cumulative SDoH burden was associated with a greater prevalence of diabetes, tobacco use, and cognitive impairment. Cumulative SDoH was not associated with neuroimaging biomarkers (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). Greater cumulative SDoH burden showed an independent association with poor memory, executive function, and processing speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01)\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings identified social and structural factors that were linked to cardiometabolic risk and cognitive health among NHB men; however, cumulative SDoH burden was not independently associated with white matter hyperintensities or hippocampal volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bsa3.70100","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:55:38Z","timestamp":1784955338000},"source":"Crossref","is-referenced-by-count":0,"title":["Unfavorable social determinants of health are associated with lower cognitive performance in non\u2010Hispanic black men: the HABS\u2010HD Study"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-2309","authenticated-orcid":false,"given":"Raymond","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Medicine University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"},{"name":"Center for Exercise Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-9456","authenticated-orcid":false,"given":"Cellas A.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, School of Medicine Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8871-4282","authenticated-orcid":false,"given":"Michael J.","family":"Hankes","sequence":"additional","affiliation":[{"name":"Center for Exercise Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"School of Health Professions University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Roland J.","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Program for Research on Men's Health Johns Hopkins Center for Health Disparities Solutions Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Health and Aging Brain Study (HABS\u2010HD) Study 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