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However, men often feel too embarrassed to receive a semen analysis in the hospital due to social stigmas. To overcome this problem, we developed a 3\u2010(4,5\u2010Dimethyl\u20102\u2010thiazolyl)\u20102,5\u2010diphenyl\u20102H\u2010tetrazolium bromide test strip to distinguish semen samples with low total motile sperm concentration from those with normal motile sperm concentration. This is a point\u2010of\u2010care colorimetric semen analytical method with a one\u2010step, inexpensive, equipment\u2010free evaluation process, and adequate accuracy validated in a 42\u2010sample clinical trial. In this study, results were evaluated visually and with a smartphone application. Using visual observation methods, the area under the curve (AUC) was 0.71 (95% of confidence interval = 0.55\u20130.86;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.021), sensitivity was 41%, specificity was 95%, positive predictive value was 90%, negative predictive value (NPV) was 59.4%, and accuracy was 67%. Using a smartphone recording and analytical system, AUC was 0.766 (95% of confidence interval = 0.612\u20130.92;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003), sensitivity was 96%, specificity was 65%, PPV was 75%, NPV was 92.9%, and accuracy was 80.9%. This work demonstrated a screening tool that could elevate semen analysis to the level of routine healthcare and provide for private, in\u2010home self\u2010assessment.\n                  <\/jats:p>","DOI":"10.1002\/btm2.10176","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T02:53:55Z","timestamp":1596077635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Point\u2010of\u2010care semen analysis of patients with infertility via smartphone and colorimetric paper\u2010based diagnostic device"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6231-6014","authenticated-orcid":false,"given":"Yu\u2010Ting","family":"Tsao","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering National Tsing Hua University  Hsinchu Taiwan"},{"name":"Department of Education Chang Gung Memorial Hospital Linkou Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Research and Development Hygeia Touch Inc.  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Chiao","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Education Chang Gung Memorial Hospital Linkou Branch  Taoyuan Taiwan"},{"name":"School of Traditional Chinese Medicine Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Chang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chang Gung Memorial Hospital Linkou Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering Okayama University of Science  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering National Tsing Hua University  Hsinchu 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