{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:44:42Z","timestamp":1790073882241,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013223","name":"Chongqing Research Program of Basic Research and Frontier Technology","doi-asserted-by":"publisher","award":["cstc2018jcyjAX0612"],"award-info":[{"award-number":["cstc2018jcyjAX0612"]}],"id":[{"id":"10.13039\/501100013223","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering &amp;amp; Transla Med"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )\u2010induced liver injury is predominantly caused by free radicals, in which mitochondrial function of hepatocytes is impaired, accompanying with the production of ROS and decreased ATP energy supply in animals intoxicated with CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Here we explored a novel therapeutic approach, mitochondrial transplantation therapy, for treating the liver injury. The results showed that mitochondria entered hepatocytes through macropinocytosis pathway, and thereby cell viability was recovered in a concentration\u2010dependent manner. Mitochondrial therapy could increase ATP supply and reduce free radical damage. In liver injury model of mice, mitochondrial therapy significantly improved liver function and prevented tissue fibrogenesis. Transcriptomic data revealed that mitochondrial unfold protein response (UPR\n                    <jats:sup>mt<\/jats:sup>\n                    ), a protective transcriptional response of mitochondria\u2010to\u2010nuclear retrograde signaling, would be triggered after mitochondrial administration. Then the anti\u2010oxidant genes were up\u2010regulated to scavenge free radicals. The mitochondrial function was rehabilitated through the transcriptional activation of respiratory chain enzyme and mitophage\u2010associated genes. The protective response re\u2010balanced the cellular homeostasis, and eventually enhanced stress resistance that is linked to cell survival. The efficacy of mitochondrial transplantation therapy in the animals would suggest a novel approach for treating liver injury caused by toxins.\n                  <\/jats:p>","DOI":"10.1002\/btm2.10209","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T09:37:51Z","timestamp":1608284271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Mitochondrial transplantation therapy inhibit carbon tetrachloride\u2010induced liver injury through scavenging free radicals and protecting hepatocytes"],"prefix":"10.1002","volume":"6","author":[{"given":"Zizhen","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Southwest University  Chongqing 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