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However, long\u2010term implantation is usually associated with complications, such as capsular contracture due to excessive local inflammatory response, subsequently requiring implant removal. Therefore, modification of the silicone surface to reduce a risk of capsular contracture has attracted increasing attention. Human adipose\u2010derived stem cells (hASCs) are known to provide potentially therapeutic applications for tissue engineering, regenerative medicine, and reconstructive surgery. Herein, hASCs coating on a PDMS (hASC\u2010PDMS) or itaconic acid (IA)\u2010conjugated PDMS (hASC\u2010IA\u2010PDMS) surface is examined to determine its biocompatibility for reducing capsular contracture on the PDMS surface. In vitro cell cytotoxicity evaluation showed that hASCs on IA\u2010PDMS exhibit higher cell viability than hASCs on PDMS. A lower release of proinflammatory cytokines is observed in hASC\u2010PDMS and hASC\u2010IA\u2010PDMS compared to the cells on plate. Multiple factors, including in vivo mRNA expression levels of cytokines related to fibrosis; number of inflammatory cells; number of macrophages and myofibroblasts; capsule thickness; and collagen density following implantation in rats for 60\u2009days, indicate that incorporated coating hASCs on PDMSs most effectively reduces capsular contracture. This study demonstrates the potential of hASCs coating for the modification of PDMS surfaces in enhancing surface biocompatibility for reducing capsular contracture of PDMS\u2010based medical devices.<\/jats:p>","DOI":"10.1002\/btm2.10260","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:27:51Z","timestamp":1632292071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Assessment of human\n                    <scp>adipose\u2010derived<\/scp>\n                    stem cell on\n                    <scp>surface\u2010modified<\/scp>\n                    silicone implant to reduce capsular contracture formation"],"prefix":"10.1002","volume":"7","author":[{"given":"Chanutchamon","family":"Sutthiwanjampa","sequence":"first","affiliation":[{"name":"School of Integrative Engineering, Chung\u2010Ang University  Seoul Republic of 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