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During the progression of alkali burn\u2010induced injury, overwhelmed oxidative stress in the cornea triggers cell damage, including oxidative changes in cellular macromolecules and lipid peroxidation in membranes, leading to impaired corneal transparency, decreased vision, or even blindness. In this study, we identified that ferroptosis, a type of lipid peroxidation\u2010dependent cell death, mediated alkali burn\u2010induced corneal injury. Ferroptosis\u2010targeting therapy protected the cornea from cell damage and neovascularization. However, the specific ferroptosis inhibitor ferrostatin\u20101 (Fer\u20101) is hydrophobic and cannot be directly applied in the clinic. Therefore, we developed Fer\u20101\u2010loaded liposomes (Fer\u20101\u2010NPs) to improve the bioavailability of Fer\u20101. Our study demonstrated that Fer\u20101\u2010NPs exerted remarkable curative effects regarding corneal opacity and neovascularization in vivo. The efficacy was comparable to that of dexamethasone, but without appreciable side effects. The significant suppression of ferroptosis (induced by lipid peroxidation and mitochondria disruption), inflammation, and neovascularization might be the mechanisms underlying the therapeutic effect of Fer\u20101\u2010NPs. Moreover, the Fer\u20101\u2010NPs treatment showed no signs of cytotoxicity, hematologic toxicity, or visceral organ damage, which further confirmed the biocompatibility. Overall, Fer\u20101\u2010NPs provide a new prospect for safe and effective therapy for corneal alkali burn.<\/jats:p>","DOI":"10.1002\/btm2.10276","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T03:29:40Z","timestamp":1638415780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Ferrostatin\u20101\u2010loaded liposome for treatment of corneal alkali burn via targeting ferroptosis"],"prefix":"10.1002","volume":"7","author":[{"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, the Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou 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