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Specialized proresolution mediators are powerful agents of resolution but have a short in vivo half\u2010life. In this study, we have engineered a Resolvin D1 (RvD1)\u2010loaded nanoliposomal formulation (Lipo\u2010RvD1) that targets and resolves the OA\u2010associated inflammation. This formulation creates a depot of the RvD1 molecules that allows the controlled release of the molecule for up to 11\u2009days in vitro. In surgically induced mice model of OA, only controlled\u2010release formulation of Lipo\u2010RvD1 was able to treat the progressing cartilage damage when administered a month after the surgery, while the free drug was unable to prevent cartilage damage. We found that Lipo\u2010RvD1 functions by damping the proinflammatory activity of synovial macrophages and recruiting a higher number of M2 macrophages at the site of inflammation. Our Lipo\u2010RvD1 formulation was able to target and suppress the formation of the osteophytes and showed analgesic effect, thus emphasizing its ability to treat clinical symptoms of OA. Such controlled\u2010release formulation of RvD1 could represent a patient\u2010compliant treatment for OA.<\/jats:p>","DOI":"10.1002\/btm2.10281","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T08:29:14Z","timestamp":1639643354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Resolvin\n                    <scp>D1<\/scp>\n                    \u2010loaded nanoliposomes promote\n                    <scp>M2<\/scp>\n                    macrophage polarization and are effective in the treatment of osteoarthritis"],"prefix":"10.1002","volume":"7","author":[{"given":"Ameya A.","family":"Dravid","sequence":"first","affiliation":[{"name":"BioSystems Science and Engineering Indian Institute of Science  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaamini","family":"M. 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