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The transplantation of stem cells has been proved a promising way for treatment. However, the therapeutic efficacy is severely impaired by excessive cell loss and death and poor accumulation in the injury site along with the traditional implantation strategy. Herein, an EPO\u2010loaded multifunctional hydrogel was designed. The hydrogels' adhesive property and mechanical strength were enhanced by adding catechol\u2010catechol adducts, thus significantly improving adipose\u2010derived stem cells (ADSC) retention and rescuing cell loss in the injury site. Meanwhile, the sustained release of EPO effectively ameliorated the viability and paracrine activity of ADSC, leading to enhanced migration of Schwann cells and differentiation of PC12 cells in vivo. On a bilateral cavernous nerve injury rat model, the present stem cell\u2010EPO\u2010hydrogel implanted strategy could significantly alleviate erectile dysfunction. The higher expression of Tuj1 and lower expression of GFAP in the major pelvic ganglia (MPG) indicated the acceleration of neural differentiation while the suppressing development of astrocytes. Also, the combined therapy restored the expression levels of eNOs, nNOs, and \u03b1\u2010SMA in penile tissues, suggesting the rehabilitation of the penis. Further analysis of Masson trichrome staining and apoptosis evaluation of the corpus cavernosum showed the preservation of vascular endothelium content and the prevention of penile fibrosis after denervation. Overall, we believe that this combined strategy presents a promising way not only for restoring neurogenic erectile function but also for the clinical translation of stem cell therapy.<\/jats:p>","DOI":"10.1002\/btm2.10319","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:51:23Z","timestamp":1653976283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["An\n                    <scp>EPO<\/scp>\n                    \u2010loaded multifunctional hydrogel synergizing with adipose\u2010derived stem cells restores neurogenic erectile function via enhancing nerve regeneration and penile rehabilitation"],"prefix":"10.1002","volume":"7","author":[{"given":"Jun","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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