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Currently, few treatments can satisfactorily restore the structure and function of native tendon. Bioactive glass (BG) has been shown to possess immunomodulatory and angiogenic properties. In this study, we investigated whether an injectable hydrogel fabricated of BG and sodium alginate (SA) could be applied to enhance tenogenesis following suture repair of injured tendon. We demonstrated that BG\/SA hydrogel significantly accelerated tenogenesis without inducing heterotopic ossification based on histological analysis. The therapeutic effect could attribute to increased angiogenesis and M1 to M2 phenotypic switch of macrophages within 7\u2009days post\u2010surgery. Morphological characterization demonstrated that BG\/SA hydrogel partially reverted the pathological changes of Achilles tendon, including increased length and cross\u2010sectional area (CSA). Finally, biomechanical test showed that BG\/SA hydrogel significantly improved ultimate load, failure stress, and tensile modulus of the repaired tendon. In conclusion, administration of an injectable BG\/SA hydrogel can be a novel and promising therapeutic approach to augment Achilles tendon healing in conjunction with surgical intervention.<\/jats:p>","DOI":"10.1002\/btm2.10345","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T07:10:00Z","timestamp":1653721800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Injectable bioactive glass\/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-4783","authenticated-orcid":false,"given":"Hongtao","family":"Xu","sequence":"first","affiliation":[{"name":"Musculoskeletal Research Laboratory, Department of Orthopedics and Traumatology The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Innovative Orthopaedic Biomaterial and Drug 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