{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:24:45Z","timestamp":1774542285708,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering &amp;amp; Transla Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Near\u2010infrared (NIR) photothermal therapy plays a critical role in the cancer treatment and diagnosis as a promising carcinoma treatment modalities nowadays. However, development of clinical application has been greatly limited due to the inefficient drug release and low tumor accumulation. Herein, we designed a NIR\u2010light triggered indocyanine green (ICG)\u2010based PCL core\/P(MEO\n                    <jats:sub>2<\/jats:sub>\n                    MA\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010HMAM) shell nanocomposites (PPH@ICG) and evaluated their therapeutic effects in vitro and in vivo. The anticancer drug 5\u2010fluorouracil (5Fu) and the photothermal agent ICG were loaded into a thermo\u2010sensitive micelle (PPH@5Fu@ICG) by self\u2010assembly. The nanoparticles formed were characterized using transmission electron microscopy, dynamic light scattering, and fluorescence spectra. The thermo\u2010sensitive copolymer (PPH@5Fu@ICG) showed a great temperature\u2010controlled drug release response with lower critical solution temperature. In vitro cellular uptake and TEM imaging proved that PPH@5Fu@ICG nanoparticles can home into the lysosomal compartments under NIR. Moreover, in gastric tumor\u2010bearing nude mice, PPH@5Fu@ICG\u2009+\u2009NIR group exhibited excellent improvement in antitumor efficacy based on the NIR\u2010triggered thermo\u2010chemotherapy synergy, both in vitro and in vivo. In summary, the proposed strategy of synergistic photo\u2010hyperthermia chemotherapy effectively reduced the 5Fu dose, toxic or side effect, which could serve as a secure and efficient approach for cancer theranostics.\n                  <\/jats:p>","DOI":"10.1002\/btm2.10368","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T02:00:59Z","timestamp":1657677659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Photothermally responsive theranostic nanocomposites for near\u2010infrared light triggered drug release and enhanced synergism of photothermo\u2010chemotherapy for gastric cancer"],"prefix":"10.1002","volume":"8","author":[{"given":"Taicheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong China"},{"name":"Guangdong 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