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Lymph node dissection and radiation therapy for cancer treatment may lead to secondary lymphedema, which is a chronic disease induced by malfunction of lymphatic flow. The lymphatic channel sheet (LCS) is an artificial micro\u2010fluidic structure that was fabricated with polydimethylsiloxane to maintain lymphatic flow and induce lymphangiogenesis. The structure has two\u2010dimensional multichannels that increase the probability of lymphangiogenesis and allow for relatively easy application. We verified the efficacy of the lymphatic channel sheet through macroscopic and microscopic observation in small animal models, which underwent brachial lymph node dissection and irradiation. The lymphatic channel sheet enabled the successful transport of lymphatic fluid from the distal to the proximal area in place of the removed brachial lymph nodes. It prevented swelling and abnormal lymphatic drainage during the follow\u2010up period. Lymphangiogenesis was also identified inside the channel by histological analysis after 8\u2009weeks. According to these experimental results, we attest to the roles of the lymphatic channel sheet as a lymphatic pathway and scaffold in the rat upper limb model of secondary lymphedema. The lymphatic channel sheet maintained lymphatic flow after lymph node dissection and irradiation in an environment where lymph flow is cut off. It also relieved symptoms of secondary lymphedema by providing a lymph\u2010friendly space and inducing lymphangiogenesis.<\/jats:p>","DOI":"10.1002\/btm2.10371","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T02:40:27Z","timestamp":1657075227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lymphatic channel sheet of polydimethylsiloxane for preventing secondary lymphedema in the rat upper limb model"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6181-7768","authenticated-orcid":false,"given":"Hwayeong","family":"Cheon","sequence":"first","affiliation":[{"name":"Biomedical Engineering Research Center Asan Institute for Life Sciences, Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-1426","authenticated-orcid":false,"given":"Ma. 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