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Currently, clinical abuse of antibiotics encouraged the evolution of resistant bacteria. Conventional antibiotic eye drops based keratitis treatment has been heavily restricted due to the lack of bactericidal efficiency and easy induction of bacterial resistance. Hence, developing an effective treatment strategy for bacterial keratitis is of great significance. In this work, we investigated \u03b5\u2010poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine (EPL)\u2010modified polydopamine (PDA) nanoparticles (EPL@PDA NPs)\u2010mediated antibacterial photothermal therapy (aPTT), to cope with methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA)\u2010induced keratitis. The surface modification of cationic peptide EPL enables EPL@PDA NPs to specifically target negatively charged MRSA and induces local hyperthermia to kill the bacteria under low ambient temperature. Under near\u2010infrared (NIR) irradiation, the sterilization efficiency of EPL@PDA NPs suspension for MRSA in vitro was up to 99.96%. The EPL@PDA\u2010mediated aPTT presented potent antibacterial efficacy in treating MRSA\u2010induced keratitis with little corneal epithelial cytotoxicity and good biocompatibility. In conclusion, the bacterial\u2010targeting aPTT platform in this work provides a prospective method for the management of MRSA\u2010induced refractory bacterial keratitis.<\/jats:p>","DOI":"10.1002\/btm2.10380","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T03:31:10Z","timestamp":1659065470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["<scp>\u03b5\u2010poly\u2010L<\/scp>\u2010lysine\u2010modified polydopamine nanoparticles for targeted photothermal therapy of drug\u2010resistant bacterial keratitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Wenjie","family":"Fan","sequence":"first","affiliation":[{"name":"Eye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou People's Republic of China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, the Second Affiliated Hospital, School of Medicine Zhejiang University  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