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While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dosing necessitates very large doses and places a substantial burden on the healthcare system. In contrast, direct inhaled delivery of mAb therapeutics offers the convenience of self\u2010dosing at home, as well as much more efficient mAb delivery to the respiratory tract. Here, building on our previous discovery of Fc\u2010mucin interactions crosslinking viruses to mucins, we showed that regdanvimab, a potent neutralizing mAb already approved for COVID\u201019 in several countries, can effectively trap SARS\u2010CoV\u20102 virus\u2010like particles in fresh human airway mucus. IN\u2010006, a reformulation of regdanvimab, was stably nebulized across a wide range of concentrations, with no loss of activity and no formation of aggregates. Finally, nebulized delivery of IN\u2010006 resulted in 100\u2010fold greater mAb levels in the lungs of rats compared to serum, in marked contrast to intravenously dosed mAbs. These results not only support our current efforts to evaluate the safety and efficacy of IN\u2010006 in clinical trials, but more broadly substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS\u2010CoV\u20102 and other respiratory pathologies.<\/jats:p>","DOI":"10.1002\/btm2.10391","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T05:44:34Z","timestamp":1661838274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Stable nebulization and muco\u2010trapping properties of regdanvimab\/\n                    <scp>IN<\/scp>\n                    \u2010006 support its development as a potent, dose\u2010saving inhaled therapy for\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1002","volume":"8","author":[{"given":"Morgan D.","family":"McSweeney","sequence":"first","affiliation":[{"name":"Inhalon Biopharma Inc  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