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However, most of the physiological motor behaviors and movement disorders, such as gait, balance, tremor, dystonia, and myoclonus, are highly dependent on the overall momentum of the whole\u2010body movements. Therefore, tracking the targeted movement and overall momentum simultaneously is critical for motor control research, but it remains an unmet need. Here, we introduce the intrinsic oscillatory property (IOP), a fundamental mechanical principle of physics, as a method for motion tracking in a force plate. The overall kinetic energy of animal motions can be transformed into the oscillatory amplitudes at the designed IOP frequency of the force plate, while the target movement has its own frequency features and can be tracked simultaneously. Using action tremor as an example, we reported that force plate\u2010based IOP approach has superior performance and reliability in detecting both tremor severity and tremor frequency, showing a lower level of coefficient of variation (CV) compared with video\u2010 and accelerometer\u2010based motion tracking methods and their combination. Under the locomotor suppression effect of medications, therapeutic effects on tremor severity can still be quantified by dynamically adjusting the overall locomotor activity detected by IOP. We further validated IOP method in optogenetic\u2010induced movements and natural movements, confirming that IOP can represent the intensity of general rhythmic and nonrhythmic movements, thus it can be generalized as a common approach to study kinematics.<\/jats:p>","DOI":"10.1002\/btm2.10432","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T04:07:58Z","timestamp":1666411678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics"],"prefix":"10.1002","volume":"8","author":[{"given":"Chun\u2010Lun","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Neurology Columbia University  New York New York USA"},{"name":"The Initiative for Columbia Ataxia and Tremor  New York New York USA"},{"name":"Department of Biochemistry and Molecular Biology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-6202","authenticated-orcid":false,"given":"Yi\u2010Ting","family":"Lin","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center, National Taiwan University  Taipei City Taiwan"},{"name":"Department of Psychology National Taiwan University  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Yin","family":"Lu","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center, National Taiwan University  Taipei City Taiwan"},{"name":"Institute of Biomedical Sciences, Academia Sinica  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Huei","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center, National Taiwan University  Taipei City Taiwan"},{"name":"Institute of Biomedical Sciences, Academia Sinica  Taipei City Taiwan"},{"name":"Department and Graduate Institute of Pharmacology National Taiwan University College of Medicine  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center, National Taiwan University  Taipei City Taiwan"},{"name":"Institute of Biomedical Sciences, Academia Sinica  Taipei City Taiwan"},{"name":"Department and Graduate Institute of Pharmacology National Taiwan University College of Medicine  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Han","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University  New York New York USA"},{"name":"The Initiative for Columbia Ataxia and Tremor  New York New York 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