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In this study, we described the clinical translation of ILs containing KCZ (KCZ\u2010ILs) from the lab into the clinic and evaluated the efficacy and safety of KCZ\u2010ILs in patients with tinea pedis. Thirty\u2010six enrolled participants were randomized to receive either KCZ\u2010ILs (KCZ, 4.72\u2009mg\/g) or Daktarin\u00ae (control group; KCZ, 20\u2009mg\/g) topically twice daily, making the lesion be covered with a thin layer of medication. The randomized controlled trial lasted for 8\u2009weeks including 4\u2009weeks of intervention and 4\u2009weeks of follow\u2010up. Primary efficacy outcome was the proportion of treatment success responders, defined as patients achieving negative mycological result and \u226560% relative reduction in total clinical symptom score (TSS) from baseline at week 4. Secondary outcomes mainly for evaluating the relapse of disease included the proportion of treatment success individuals at week 8 and fungal recurrence rate at weeks 2, 3, 4, and 8. After 4\u2009weeks of medication, 47.06% of the KCZ\u2010ILs subjects were treatment successes compared with only 25.00% of those using Daktarin\u00ae. Throughout the trial period, KCZ\u2010ILs induced a significantly lower recurrence rate (52.94%) than that of control patients (68.75%). Furthermore, KCZ\u2010ILs were found to be safe and well\u2010tolerated. In conclusion, ILs loading only 1\/4 KCZ dose of Daktarin\u00ae showed a better efficacy and safety profile in the management of tinea pedis, creating a new opportunity for the treatment of skin diseases caused by fungal infection and is worthy of clinical application.<\/jats:p>","DOI":"10.1002\/btm2.10463","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T06:17:15Z","timestamp":1669961835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the efficacy and safety of ionic liquids containing ketoconazole in patients with tinea pedis: A randomized controlled clinical trial"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-4927","authenticated-orcid":false,"given":"Xiying","family":"Wu","sequence":"first","affiliation":[{"name":"Shanghai Skin Disease Hospital Tongji University School of Medicine  Shanghai 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