{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:38:25Z","timestamp":1789094305371,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aiche.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering &amp; Transla Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Application of intermittent forces by vibration is proposed as an easy\u2010to\u2010use accelerator of dental movement. The purpose of this study was to determine the effect of intermittent vibrational force application during orthodontic aligner treatment on receptor activator of nuclear factor\u2010kappa B ligand (RANKL) and osteoprotegerin (OPG) concentrations in crevicular fluid as markers of bone remodeling. This three\u2010arm parallel randomized clinical trial included 45 candidates for malocclusion treatment with aligners, randomly assigned to: Group A (vibrational forces from onset of treatment); Group B (vibrational forces at 6\u2009weeks after treatment onset); or Group C (no vibration). The frequency of aligner adjustment also differed among groups. At different time points, a paper tip was used to draw crevicular fluid samples from a moving lower incisor for RANKL and OPG analysis using ELISA kits. Mixed\u2010model ANOVA found no significant differences in RANKL (A:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.31, B:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.8, C:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.49) or OPG (A:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.24, B:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.58, C:\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.59) over time in any group or as a function of the application\/non\u2010application of vibration or the frequency of aligner adjustments. Application of this accelerator device did not significantly affect bone remodeling in patients undergoing orthodontic treatment with aligners. However, a nonsignificant improvement in biomarker concentrations was observed when aligners were changed every 7\u2009days and vibration was also applied. Further research is warranted to establish protocols for the application of vibration and the timing of aligner adjustments.\n                  <\/jats:p>","DOI":"10.1002\/btm2.10491","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T05:03:05Z","timestamp":1680325385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Randomized clinical trial on the effect of intermittent vibrational force application during orthodontic treatment with aligners on\n                    <scp>RANKL<\/scp>\n                    and\n                    <scp>OPG<\/scp>\n                    concentrations in crevicular fluid"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-8340","authenticated-orcid":false,"given":"Alicia","family":"P\u00e9rez Idarraga","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Odontology University Complutense Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fara","family":"Yeste Ojeda","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Universidad San Pablo CEU  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Virto Ruiz","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases), Research Group Universidad Complutense Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Lacasa Litner","sequence":"additional","affiliation":[{"name":"Department of Orthodontics CEPUME, Universidad de Alcal\u00e1 de Henares, Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cacho Casado","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Odontology University Complutense Madrid  Madrid Spain"},{"name":"BIOCRAN (Craniofacial Biology: Orthodontics and Dentofacial Orthopedics), Research Group University Complutense Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conchita","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Odontology University Complutense Madrid  Madrid Spain"},{"name":"BIOCRAN (Craniofacial Biology: Orthodontics and Dentofacial Orthopedics), Research Group University Complutense Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sodo.2012.06.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.odw.2012.05.004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2009.01444.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/105873"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2012.08.026"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2006.00368.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2006.01.046"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600708"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515576195"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_12_12_1","first-page":"3","article-title":"A 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