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Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally, antibiotics are often associated with adverse reactions. Hence, improved antibiotic therapies are required for safer and effective DFI management. On this regard, drug delivery systems (DDSs) constitute a promising strategy. We propose a gellan gum (GG)\u2010based spongy\u2010like hydrogel as a topical and controlled DDS of vancomycin and clindamycin, for an improved dual antibiotic therapy against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) in DFI. The developed DDS presents suitable features for topical application, while promoting the controlled release of both antibiotics, resulting in a significant reduction of in vitro antibiotic\u2010associated cytotoxicity without compromising antibacterial activity. The therapeutic potential of this DDS was further corroborated in vivo, in a diabetic mouse model of MRSA\u2010infected wounds. A single DDS administration allowed a significant bacterial burden reduction in a short period of time, without exacerbating host inflammatory response. Taken together, these results suggest that the proposed DDS represents a promising strategy for the topical treatment of DFI, potentially overcoming limitations associated with systemic antibiotic administration and minimizing the frequency of administration.\n                  <\/jats:p>","DOI":"10.1002\/btm2.10504","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T05:49:27Z","timestamp":1679377767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Gellan gum spongy\u2010like hydrogel\u2010based dual antibiotic therapy for infected diabetic wounds"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-0784","authenticated-orcid":false,"given":"Ana Isabel","family":"Mendes","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho  Braga 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Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-4888","authenticated-orcid":false,"given":"Jorge","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho  Braga Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory  Braga\/Guimar\u00e3es 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